Development Level

Tbio 38 | 10,625
Tchem 27 | 1,890
Tclin 13 | 602
Tdark 1 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal head morphology 2 | 10
decreased bone mineral content 2 | 157
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
short tibia 2 | 82
abnormal bone mineralization 1 | 55
abnormal cervical vertebrae mo... 1 | 4
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal rib morphology 1 | 28
abnormal sacral vertebrae morp... 1 | 5
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
cataract 1 | 26
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased coping response 1 | 5
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating serum al... 1 | 25
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
preweaning lethality, incomple... 1 | 260
rib fusion 1 | 2
vertebral fusion 1 | 23

Disease

Pancreatic Neoplasm 79 | 79
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 79 | 17,995
Female tissues 78 | 18,647
Nervous System 78 | 18,561
Cardiovascular System 77 | 17,958
Digestive Tract 77 | 18,473
Endocrine System 77 | 18,512
Skin and soft tissues 77 | 18,115
Male tissues 76 | 17,969
Urinary Tract 76 | 18,444
Liver and Pancreas 75 | 18,136
Respiratory system 74 | 17,484

Target Family

Non-IDG 42 | 11,971
Enzyme 15 | 4,146
Transcription Factor 10 | 1,400
GPCR 5 | 406
Kinase 3 | 634
Nuclear Receptor 2 | 48
Ion Channel 1 | 341
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Krueppel-like factor 5 KLF5 Tchem Transcription Factor -2.15588 189.7 186
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34160 1960.9 1181
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.03668 12041.6 648
Tissue factor pathway inhibitor 2 TFPI2 Tbio Non-IDG -2.26010 224.3 273
Tuberin TSC2 Tbio Non-IDG -2.94615 933.5 1483
CASP8 and FADD-like apoptosis regulator CFLAR Tchem Non-IDG -2.85930 837.3 538
Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A Tbio Non-IDG -2.57552 356.6 214