Development Level

Tbio 155 | 10,625
Tchem 51 | 1,890
Tclin 28 | 602
Tdark 23 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

decreased body weight 7 | 174
preweaning lethality, complete... 7 | 633
decreased lean body mass 6 | 195
decreased body length 4 | 108
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
abnormal behavior 3 | 226
abnormal bone mineralization 3 | 55
abnormal startle reflex 3 | 14
decreased bone mineral content 3 | 157
decreased circulating choleste... 3 | 85
decreased circulating insulin ... 3 | 75
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
embryonic lethality prior to t... 3 | 187
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
preweaning lethality, incomple... 3 | 260
short tibia 3 | 82
abnormal coat/hair pigmentatio... 2 | 54
abnormal cranium morphology 2 | 32
abnormal epididymis morphology 2 | 31
abnormal femur morphology 2 | 14
abnormal head morphology 2 | 10
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased circulating glucose ... 2 | 121
decreased circulating iron lev... 2 | 25
decreased circulating triglyce... 2 | 83
decreased hematocrit 2 | 25
decreased monocyte cell number 2 | 28
decreased startle reflex 2 | 48
enlarged heart 2 | 111
increased bone mineral content 2 | 92
increased circulating amylase ... 2 | 13
increased mean corpuscular vol... 2 | 91
limb grasping 2 | 35
small testis 2 | 37
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 2
abnormal lung morphology 1 | 15
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal sacral vertebrae morp... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 2
abnormal vertebral arch morpho... 1 | 9
absent startle reflex 1 | 15
decreased KLRG1-positive T-hel... 1 | 2
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased caudal vertebrae num... 1 | 8
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
polydactyly 1 | 22
prenatal lethality 1 | 16
shortened QRS complex duration 1 | 1
thrombocytopenia 1 | 46

Disease

Osteoporosis 257 | 257
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 253 | 18,473
Nervous System 253 | 18,561
Urinary Tract 253 | 18,444
Endocrine System 252 | 18,512
Female tissues 252 | 18,647
Liver and Pancreas 250 | 18,136
Cardiovascular System 249 | 17,958
Skin and soft tissues 249 | 18,115
Blood and immune system 247 | 17,995
Male tissues 246 | 17,969
Respiratory system 245 | 17,484

Target Family

Non-IDG 144 | 11,971
Enzyme 64 | 4,146
Transcription Factor 16 | 1,400
Kinase 9 | 634
GPCR 7 | 406
Ion Channel 5 | 341
Nuclear Receptor 5 | 48
Transporter 5 | 473
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
ERC protein 2 ERC2 Tbio Non-IDG -1.59613 39.1 32
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137