Development Level

Tbio 238 | 11,651
Tchem 58 | 1,388
Tclin 41 | 612
Tdark 26 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
preweaning lethality, incomple... 10 | 499
increased total body fat amoun... 9 | 134
decreased body weight 8 | 161
decreased lean body mass 8 | 135
decreased bone mineral content 7 | 151
decreased bone mineral density 7 | 126
embryonic lethality prior to t... 7 | 278
abnormal behavior 6 | 298
decreased grip strength 6 | 116
decreased vertical activity 6 | 208
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased total body fat amoun... 5 | 207
enlarged heart 5 | 210
increased blood urea nitrogen ... 5 | 48
increased circulating HDL chol... 5 | 80
short tibia 5 | 97
abnormal seminal vesicle morph... 4 | 114
abnormal startle reflex 4 | 15
cataract 4 | 92
decreased body length 4 | 101
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
embryonic lethality prior to o... 4 | 239
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
abnormal bone structure 3 | 187
abnormal coat-hair pigmentatio... 3 | 64
decreased circulating aspartat... 3 | 34
decreased hematocrit 3 | 46
embryonic growth retardation 3 | 106
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased heart weight 3 | 62
increased lean body mass 3 | 172
abnormal brain morphology 2 | 13
abnormal coat- hair morphology 2 | 19
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
absent startle reflex 2 | 24
decreased circulating alanine ... 2 | 47
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased circulating amylase ... 2 | 25
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased vertical activity 2 | 24
limb grasping 2 | 41
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal lung morphology 1 | 26
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
thin ventricular wall 1 | 24

Disease

Osteoporosis 363 | 363
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 351 | 18,159
Digestive Tract 343 | 17,369
Female tissues 342 | 17,400
Male tissues 340 | 17,142
Liver and Pancreas 338 | 16,750
Skin and soft tissues 338 | 17,230
Nervous System 337 | 16,725
Urinary Tract 334 | 16,678
Respiratory system 331 | 16,393
Blood and immune system 330 | 16,909
Cardiovascular System 300 | 15,192

Target Family

Non-IDG 183 | 12,091
Enzyme 105 | 4,145
Transcription Factor 23 | 1,400
Kinase 14 | 634
GPCR 10 | 408
Transporter 10 | 473
Nuclear Receptor 8 | 48
Ion Channel 6 | 344
Epigenetic 2 | 242
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Zinc finger protein 518B ZNF518B Tdark Non-IDG -0.25756 2.11 12
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075