Development Level

Tbio 113 | 11,178
Tchem 44 | 1,885
Tclin 17 | 612
Tdark 5 | 6,569

Collection

GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

preweaning lethality, complete... 18 | 979
hyperactivity 5 | 148
decreased total body fat amoun... 4 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal head morphology 2 | 10
decreased circulating glucose ... 2 | 126
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatine... 1 | 4
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
long tibia 1 | 25
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1

Disease

Osteoarthritis 179 | 179
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 176 | 18,159
Female tissues 175 | 17,400
Digestive Tract 174 | 17,369
Skin and soft tissues 174 | 17,230
Liver and Pancreas 171 | 16,750
Male tissues 171 | 17,142
Nervous System 170 | 16,725
Blood and immune system 169 | 16,909
Urinary Tract 169 | 16,678
Respiratory system 165 | 16,393
Cardiovascular System 159 | 15,192

Target Family

Non-IDG 95 | 12,091
Enzyme 56 | 4,145
Transcription Factor 7 | 1,400
GPCR 6 | 408
Transporter 5 | 473
Kinase 4 | 634
Ion Channel 3 | 344
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Bone sialoprotein 2 IBSP Tbio Non-IDG -2.95483 756.8 261
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Semaphorin-3D SEMA3D Tbio Non-IDG -1.67367 50.4 110
Protocadherin gamma-A12 PCDHGA12 Tdark Non-IDG -0.76459 6.67 17
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479
Collagen alpha-3(IX) chain COL9A3 Tbio Non-IDG -1.35534 21.6 115
Partitioning defective 3 homolog B PARD3B Tbio Non-IDG -0.83869 7.22 31
Histone-lysine N-methyltransferase, H3 lysine-79 specific DOT1L Tchem Epigenetic -2.29797 199.6 330
Indian hedgehog protein IHH Tbio Non-IDG -2.61880 417.4 375