Development Level

Tbio 197 | 11,445
Tclin 22 | 613
Tchem 18 | 1,598
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 42 | 979
embryonic lethality prior to o... 10 | 239
abnormal behavior 9 | 298
embryonic lethality prior to t... 7 | 278
hyperactivity 7 | 148
enlarged heart 6 | 210
decreased body weight 5 | 161
hypoactivity 5 | 132
increased lean body mass 5 | 172
abnormal heart morphology 3 | 162
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased circulating phosphat... 3 | 26
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
male infertility 3 | 123
abnormal bone structure 2 | 187
abnormal coat- hair morphology 2 | 19
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating potassiu... 2 | 29
increased or absent threshold ... 2 | 101
macrophthalmia 2 | 2
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
prolonged PR interval 2 | 15
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
absent adrenal gland 1 | 2
absent lymph nodes 1 | 3
absent vibrissae 1 | 12
anophthalmia 1 | 33
convulsive seizures 1 | 13
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
enlarged spleen 1 | 41
enlarged thymus 1 | 5
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased startle reflex 1 | 112
long tibia 1 | 25
prenatal lethality 1 | 28
vertebral fusion 1 | 23

Disease

Optic Atrophy 242 | 242
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 236 | 18,159
Digestive Tract 235 | 17,369
Female tissues 235 | 17,400
Skin and soft tissues 234 | 17,230
Male tissues 233 | 17,142
Nervous System 233 | 16,725
Blood and immune system 232 | 16,909
Liver and Pancreas 232 | 16,750
Urinary Tract 231 | 16,678
Respiratory system 226 | 16,393
Cardiovascular System 216 | 15,192

Target Family

Non-IDG 115 | 12,091
Enzyme 96 | 4,145
Kinase 9 | 634
Transcription Factor 6 | 1,400
Transporter 6 | 473
Ion Channel 4 | 344
GPCR 2 | 408
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibroblast growth factor receptor 2 FGFR2 Tclin Kinase -3.08664 1210.6 948
Tuberin TSC2 Tbio Non-IDG -2.99381 1000.6 1632
cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A Tbio Enzyme -2.37476 257.4 258
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Gap junction alpha-1 protein GJA1 Tbio Non-IDG -3.59195 4122.5 889
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Hamartin TSC1 Tbio Non-IDG -2.25451 173.9 1622
Transcriptional regulator ATRX ATRX Tbio Non-IDG -2.85277 705.9 248
Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 Tbio Enzyme -2.10178 116.1 292
Dynamin-1-like protein DNM1L Tbio Non-IDG -2.65717 476.9 426