Development Level

Tbio 423 | 11,651
Tchem 152 | 1,388
Tclin 79 | 612
Tdark 24 | 6,593

Collection

RFA-RM-18-021 7 | 328
GPCR: IDG Consortium (Targets) 4 | 126
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 44 | 979
preweaning lethality, incomple... 22 | 499
abnormal bone structure 19 | 187
increased total body fat amoun... 19 | 134
decreased vertical activity 18 | 208
abnormal behavior 14 | 298
decreased bone mineral content 13 | 151
decreased bone mineral density 13 | 126
decreased lean body mass 13 | 135
enlarged heart 13 | 210
embryonic lethality prior to t... 12 | 278
increased circulating alkaline... 12 | 122
increased startle reflex 12 | 112
abnormal embryo size 11 | 220
abnormal seminal vesicle morph... 11 | 114
decreased total body fat amoun... 11 | 207
hypoactivity 11 | 132
increased lean body mass 11 | 172
decreased circulating choleste... 10 | 93
increased circulating choleste... 10 | 66
short tibia 10 | 97
abnormal heart morphology 9 | 162
decreased circulating HDL chol... 9 | 68
impaired glucose tolerance 9 | 75
increased mean corpuscular vol... 9 | 92
decreased body length 8 | 101
decreased body weight 8 | 161
abnormal gait 7 | 69
decreased grip strength 7 | 116
decreased startle reflex 7 | 75
embryonic lethality prior to o... 7 | 239
increased circulating triglyce... 7 | 42
increased heart weight 7 | 62
small superior vagus ganglion 7 | 74
abnormal locomotor behavior 6 | 24
abnormal retina morphology 6 | 71
decreased circulating LDL chol... 6 | 38
decreased circulating glucose ... 6 | 126
decreased lymphocyte cell numb... 6 | 83
hyperactivity 6 | 148
increased circulating HDL chol... 6 | 80
increased fasted circulating g... 6 | 76
increased or absent threshold ... 6 | 101
small testis 6 | 58
abnormal bone mineralization 5 | 38
abnormal epididymis morphology 5 | 42
abnormal kidney morphology 5 | 65
abnormal lens morphology 5 | 81
abnormal testis morphology 5 | 43
decreased circulating creatini... 5 | 39
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular vol... 5 | 79
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased circulating serum al... 5 | 22
increased mean corpuscular hem... 5 | 96
increased red blood cell distr... 5 | 34
limb grasping 5 | 41
prolonged ST segment 5 | 36
abnormal behavioral response t... 4 | 66
abnormal eye morphology 4 | 68
cataract 4 | 92
decreased blood urea nitrogen ... 4 | 51
decreased circulating alkaline... 4 | 46
decreased circulating aspartat... 4 | 34
decreased circulating calcium ... 4 | 36
decreased circulating serum al... 4 | 82
decreased heart weight 4 | 27
decreased prepulse inhibition 4 | 82
decreased threshold for audito... 4 | 26
increased bone mineral density 4 | 72
increased circulating alanine ... 4 | 13
increased circulating amylase ... 4 | 25
increased circulating iron lev... 4 | 30
increased leukocyte cell numbe... 4 | 47
increased vertical activity 4 | 24
prolonged QT interval 4 | 38
small thymus 4 | 16
thrombocytopenia 4 | 56
tremors 4 | 39
vertebral fusion 4 | 23
abnormal retinal vasculature m... 3 | 27
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased lactate dehydrogenas... 3 | 16
decreased spleen weight 3 | 10
embryonic growth retardation 3 | 106
increased circulating aspartat... 3 | 15
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
male infertility 3 | 123
prenatal lethality prior to he... 3 | 87

Disease

Obesity 678 | 678
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,519
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,577
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,290
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,954
invasive ductal carcinoma 2,951 | 2,950
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,744
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,695
breast carcinoma 1,638 | 1,637
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,108
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 658 | 18,159
Digestive Tract 652 | 17,369
Female tissues 645 | 17,400
Skin and soft tissues 639 | 17,230
Liver and Pancreas 625 | 16,750
Male tissues 625 | 17,142
Nervous System 622 | 16,725
Urinary Tract 621 | 16,678
Blood and immune system 619 | 16,909
Respiratory system 606 | 16,393
Cardiovascular System 554 | 15,192

Target Family

Non-IDG 308 | 12,091
Enzyme 173 | 4,145
Transcription Factor 56 | 1,400
GPCR 45 | 408
Kinase 32 | 634
Transporter 23 | 473
Epigenetic 15 | 242
Nuclear Receptor 14 | 48
Ion Channel 10 | 344
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Suppressor of SWI4 1 homolog PPAN-P2RY11 Tbio Non-IDG -2.66392 881.0 97
Angiopoietin-like protein 8 ANGPTL8 Tbio Non-IDG -2.07410 141.2 93