Development Level

Tbio 340 | 10,625
Tchem 170 | 1,890
Tclin 66 | 602
Tdark 40 | 7,003

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 24 | 633
abnormal bone structure 12 | 131
preweaning lethality, incomple... 12 | 260
decreased bone mineral density 11 | 126
decreased lean body mass 11 | 195
embryonic lethality prior to t... 11 | 187
increased circulating choleste... 10 | 53
increased or absent threshold ... 10 | 128
decreased body weight 9 | 174
decreased bone mineral content 9 | 157
decreased total body fat amoun... 9 | 186
abnormal behavior 8 | 226
abnormal bone mineralization 8 | 55
abnormal embryo size 8 | 112
decreased grip strength 8 | 123
increased mean corpuscular hem... 8 | 93
short tibia 8 | 82
abnormal gait 7 | 51
decreased body length 7 | 108
decreased circulating choleste... 7 | 85
hypoactivity 7 | 89
increased circulating HDL chol... 7 | 63
abnormal retina morphology 6 | 100
decreased circulating LDL chol... 6 | 37
embryonic lethality prior to o... 6 | 148
enlarged heart 6 | 111
increased mean corpuscular vol... 6 | 91
increased total body fat amoun... 6 | 57
decreased circulating HDL chol... 5 | 77
decreased circulating chloride... 5 | 32
decreased threshold for audito... 5 | 32
increased circulating LDL chol... 5 | 15
increased heart weight 5 | 37
increased lean body mass 5 | 107
abnormal epididymis morphology 4 | 31
abnormal maxilla morphology 4 | 16
abnormal seminal vesicle morph... 4 | 47
abnormal tooth morphology 4 | 24
decreased caudal vertebrae num... 4 | 49
decreased circulating creatini... 4 | 31
decreased lactate dehydrogenas... 4 | 14
decreased rib number 4 | 59
decreased startle reflex 4 | 48
impaired glucose tolerance 4 | 52
increased circulating alkaline... 4 | 119
increased circulating aspartat... 4 | 17
increased circulating serum al... 4 | 25
increased circulating triglyce... 4 | 24
increased fasted circulating g... 4 | 68
increased hematocrit 4 | 36
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal heart morphology 3 | 51
abnormal hindbrain development 3 | 24
abnormal kidney morphology 3 | 30
abnormal neural tube closure 3 | 37
decreased T cell number 3 | 31
decreased circulating alanine ... 3 | 53
decreased circulating aspartat... 3 | 27
decreased circulating bilirubi... 3 | 14
decreased circulating calcium ... 3 | 33
decreased circulating insulin ... 3 | 75
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased hematocrit 3 | 25
decreased lumbar vertebrae num... 3 | 62
decreased prepulse inhibition 3 | 52
decreased spleen weight 3 | 13
decreased vertical activity 3 | 22
enlarged epididymis 3 | 27
enlarged liver 3 | 3
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased circulating alanine ... 3 | 11
increased circulating calcium ... 3 | 32
increased hemoglobin content 3 | 45
increased startle reflex 3 | 38
prenatal lethality prior to he... 3 | 64
vertebral fusion 3 | 23
abnormal cranium morphology 2 | 32
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
cardiovascular system phenotyp... 2 | 35
decreased IgG1 level 2 | 4
decreased circulating iron lev... 2 | 25
decreased circulating triglyce... 2 | 83
decreased hemoglobin content 2 | 53
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating bilirubi... 2 | 16
increased circulating fructosa... 2 | 11
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased grip strength 2 | 83
small testis 2 | 37
tremors 2 | 34

Disease

Obesity 616 | 616
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 610 | 18,473
Endocrine System 610 | 18,512
Female tissues 610 | 18,647
Nervous System 610 | 18,561
Urinary Tract 603 | 18,444
Liver and Pancreas 602 | 18,136
Skin and soft tissues 598 | 18,115
Cardiovascular System 597 | 17,958
Blood and immune system 594 | 17,995
Male tissues 593 | 17,969
Respiratory system 586 | 17,484

Target Family

Non-IDG 292 | 11,971
Enzyme 151 | 4,146
GPCR 43 | 406
Transcription Factor 41 | 1,400
Kinase 31 | 634
Transporter 22 | 473
Epigenetic 14 | 242
Nuclear Receptor 11 | 48
Ion Channel 9 | 341
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160