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Development Level

Tbio 241 | 11,445
Tclin 39 | 613
Tchem 32 | 1,598
Tdark 5 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 33 | 979
abnormal behavior 14 | 298
embryonic lethality prior to o... 13 | 239
hyperactivity 10 | 148
embryonic lethality prior to t... 9 | 278
enlarged heart 8 | 210
preweaning lethality, incomple... 8 | 499
decreased body weight 7 | 161
hypoactivity 7 | 132
decreased total body fat amoun... 6 | 207
decreased vertical activity 6 | 208
abnormal heart morphology 5 | 162
increased bone mineral density 5 | 72
limb grasping 5 | 41
abnormal embryo size 4 | 220
decreased circulating triglyce... 4 | 79
enlarged lymph nodes 4 | 37
hydrometra 4 | 53
increased circulating alkaline... 4 | 122
increased heart weight 4 | 62
increased lean body mass 4 | 172
increased mean corpuscular hem... 4 | 96
male infertility 4 | 123
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased circulating serum al... 3 | 82
enlarged spleen 3 | 41
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased fasted circulating g... 3 | 76
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
small superior vagus ganglion 3 | 74
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged uterus 2 | 11
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating phosphat... 2 | 26
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
increased startle reflex 2 | 112
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
prolonged PR interval 2 | 15
small testis 2 | 58
abnormal craniofacial morpholo... 1 | 33
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatine... 1 | 4
decreased circulating iron lev... 1 | 32
decreased neutrophil cell numb... 1 | 42
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
prenatal lethality 1 | 28
vertebral fusion 1 | 23

Disease

Nystagmus 317 | 317
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 312 | 18,159
Digestive Tract 305 | 17,369
Female tissues 304 | 17,400
Nervous System 303 | 16,725
Skin and soft tissues 303 | 17,230
Male tissues 301 | 17,142
Blood and immune system 296 | 16,909
Liver and Pancreas 295 | 16,750
Urinary Tract 294 | 16,678
Respiratory system 291 | 16,393
Cardiovascular System 270 | 15,192

Target Family

Non-IDG 137 | 12,091
Enzyme 105 | 4,145
Transcription Factor 21 | 1,400
Kinase 15 | 634
Ion Channel 12 | 344
Transporter 12 | 473
GPCR 8 | 408
Epigenetic 4 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.37513 23.0 104
Poly(A) RNA polymerase, mitochondrial MTPAP Tbio Enzyme -1.36829 24.0 68
Tetratricopeptide repeat protein 19, mitochondrial TTC19 Tbio Non-IDG -0.95371 10.6 38
Claudin-16 CLDN16 Tbio Non-IDG -1.98248 102.4 138
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74