Development Level

Tbio 296 | 11,651
Tchem 83 | 1,388
Tclin 20 | 612
Tdark 15 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 16 | 499
embryonic lethality prior to o... 15 | 239
embryonic lethality prior to t... 15 | 278
abnormal behavior 14 | 298
abnormal embryo size 10 | 220
enlarged heart 10 | 210
increased lean body mass 10 | 172
decreased circulating glucose ... 9 | 126
decreased total body fat amoun... 9 | 207
increased total body fat amoun... 9 | 134
abnormal bone structure 8 | 187
abnormal heart morphology 8 | 162
decreased grip strength 8 | 116
hypoactivity 8 | 132
abnormal gait 7 | 69
abnormal seminal vesicle morph... 7 | 114
decreased hemoglobin content 7 | 68
decreased mean corpuscular vol... 7 | 79
decreased vertical activity 7 | 208
hyperactivity 7 | 148
decreased body weight 6 | 161
increased fasted circulating g... 6 | 76
male infertility 6 | 123
decreased bone mineral density 5 | 126
decreased circulating serum al... 5 | 82
decreased fasted circulating g... 5 | 65
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular hem... 5 | 50
embryonic growth retardation 5 | 106
increased or absent threshold ... 5 | 101
limb grasping 5 | 41
abnormal retina morphology 4 | 71
decreased bone mineral content 4 | 151
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased lean body mass 4 | 135
decreased startle reflex 4 | 75
impaired glucose tolerance 4 | 75
increased blood urea nitrogen ... 4 | 48
increased body length 4 | 32
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased erythrocyte cell num... 4 | 39
increased monocyte cell number 4 | 63
increased red blood cell distr... 4 | 34
increased startle reflex 4 | 112
small testis 4 | 58
tremors 4 | 39
abnormal behavioral response t... 3 | 66
abnormal kidney morphology 3 | 65
abnormal skin morphology 3 | 50
abnormal sleep behavior 3 | 70
cataract 3 | 92
cyanosis 3 | 7
decreased basophil cell number 3 | 16
decreased body length 3 | 101
decreased circulating amylase ... 3 | 28
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased circulating sodium l... 3 | 22
decreased heart weight 3 | 27
decreased red blood cell distr... 3 | 41
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased grip strength 3 | 41
increased heart weight 3 | 62
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
thrombocytosis 3 | 27
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
cardiovascular system phenotyp... 2 | 36
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating potassiu... 2 | 20
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased prepulse inhibition 2 | 32
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
vertebral fusion 2 | 23

Disease

Neurodegenerative disease 414 | 414
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 406 | 18,159
Digestive Tract 404 | 17,369
Nervous System 404 | 16,725
Female tissues 403 | 17,400
Male tissues 401 | 17,142
Skin and soft tissues 400 | 17,230
Urinary Tract 398 | 16,678
Liver and Pancreas 395 | 16,750
Blood and immune system 394 | 16,909
Respiratory system 393 | 16,393
Cardiovascular System 378 | 15,192

Target Family

Non-IDG 230 | 12,091
Enzyme 113 | 4,145
Kinase 23 | 634
Ion Channel 15 | 344
Transporter 13 | 473
Transcription Factor 9 | 1,400
Epigenetic 6 | 242
GPCR 3 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 CHCHD2 Tbio Non-IDG -1.33813 39.8 99
Synphilin-1 SNCAIP Tbio Non-IDG -1.92755 92.1 157
Chymotrypsin-like protease CTRL-1 CTRL Tchem Enzyme -3.14577 1283.5 150
AP-4 complex subunit sigma-1 AP4S1 Tdark Non-IDG -0.68049 4.42 25
Kinase D-interacting substrate of 220 kDa KIDINS220 Tbio Enzyme -2.42897 262.3 191
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
AP-4 complex subunit beta-1 AP4B1 Tbio Non-IDG -0.79214 6.23 124
Alsin ALS2 Tbio Non-IDG -2.20492 161.9 180