Development Level

Tbio 70 | 11,445
Tchem 33 | 1,598
Tclin 18 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 4 | 187
decreased vertical activity 4 | 208
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
tremors 3 | 39
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal lung morphology 2 | 26
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased basophil cell number 2 | 16
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased fasted circulating g... 2 | 65
decreased heart weight 2 | 27
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
edema 2 | 59
hyperactivity 2 | 148
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased lymphocyte cell numb... 2 | 32
increased prepulse inhibition 2 | 32
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
small testis 2 | 58
abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spine curvature 1 | 9
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent startle reflex 1 | 24
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
enlarged heart atrium 1 | 4
hemorrhage 1 | 23
hypoactivity 1 | 132
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
premature death 1 | 5

Disease

Nerve Degeneration 121 | 121
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 120 | 18,159
Digestive Tract 118 | 17,369
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Skin and soft tissues 117 | 17,230
Nervous System 116 | 16,725
Male tissues 115 | 17,142
Blood and immune system 114 | 16,909
Urinary Tract 114 | 16,678
Respiratory system 113 | 16,393
Cardiovascular System 102 | 15,192

Target Family

Non-IDG 65 | 12,091
Enzyme 29 | 4,145
Kinase 8 | 634
Transporter 6 | 473
GPCR 4 | 408
Ion Channel 4 | 344
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Tetratricopeptide repeat protein 19, mitochondrial TTC19 Tbio Non-IDG -0.95371 10.6 38
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Galactocerebrosidase GALC Tbio Enzyme -2.56924 363.2 143
Lysosomal-trafficking regulator LYST Tbio Non-IDG -1.96473 92.5 15
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Zinc finger and BTB domain-containing protein 20 ZBTB20 Tbio Transcription Factor -2.14421 133.1 85