Development Level

Tbio 72 | 10,625
Tchem 42 | 1,890
Tclin 23 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
abnormal behavior 2 | 226
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
increased mean corpuscular vol... 2 | 91
male infertility 2 | 62
short tibia 2 | 82
small testis 2 | 37
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal sacral vertebrae morp... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal vitreous body morphol... 1 | 7
absent optic nerve 1 | 1
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
increased blood uric acid leve... 1 | 5
increased circulating chloride... 1 | 43
increased fasted circulating g... 1 | 68
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
preweaning lethality, incomple... 1 | 260
prolonged PR interval 1 | 4
small seminal vesicle 1 | 6
small superior vagus ganglion 1 | 20
thrombocytopenia 1 | 46

Disease

Neoplasm Metastasis 138 | 138
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 137 | 18,473
Endocrine System 137 | 18,512
Female tissues 137 | 18,647
Nervous System 137 | 18,561
Respiratory system 137 | 17,484
Urinary Tract 137 | 18,444
Cardiovascular System 136 | 17,958
Skin and soft tissues 136 | 18,115
Blood and immune system 135 | 17,995
Liver and Pancreas 135 | 18,136
Male tissues 134 | 17,969

Target Family

Non-IDG 70 | 11,971
Enzyme 28 | 4,146
Kinase 16 | 634
Transcription Factor 10 | 1,400
GPCR 5 | 406
Transporter 5 | 473
Epigenetic 2 | 242
Ion Channel 1 | 341
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Ferritin light chain FTL Tbio Non-IDG -2.37909 242.0 430
Elongation factor 1-beta EEF1B2 Tbio Non-IDG -1.77658 56.5 100
Peptidyl-prolyl cis-trans isomerase A PPIA Tclin Enzyme -2.94458 833.5 354
Prostaglandin G/H synthase 2 PTGS2 Tclin Enzyme -4.03668 12041.6 648
Elongation factor 2 EEF2 Tchem Non-IDG -2.93803 911.5 347