Development Level

Tbio 88 | 11,178
Tchem 55 | 1,885
Tclin 18 | 612
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased vertical activity 4 | 208
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
increased startle reflex 3 | 112
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased heart left ventricle... 2 | 28
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
abnormal QT variability 1 | 10
abnormal bone mineralization 1 | 38
abnormal coat- hair morphology 1 | 19
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal embryonic autopod pla... 1 | 2
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 3
abnormal liver size 1 | 5
abnormal ovary morphology 1 | 7
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
embryonic growth retardation 1 | 106
enlarged heart atrium 1 | 4
hypoactivity 1 | 132
increased body temperature 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
pale liver 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Myocardial Ischemia 162 | 162
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Digestive Tract 162 | 17,369
Endocrine System 162 | 18,159
Blood and immune system 161 | 16,909
Female tissues 161 | 17,400
Liver and Pancreas 161 | 16,750
Urinary Tract 161 | 16,678
Male tissues 160 | 17,142
Nervous System 160 | 16,725
Respiratory system 160 | 16,393
Skin and soft tissues 160 | 17,230
Cardiovascular System 156 | 15,192

Target Family

Non-IDG 83 | 12,091
Enzyme 42 | 4,145
Kinase 14 | 634
Transcription Factor 13 | 1,400
GPCR 3 | 408
Transporter 3 | 473
Ion Channel 2 | 344
Nuclear Receptor 2 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829
Ras-related protein Rab-12 RAB12 Tbio Enzyme -1.21868 13.9 73
E3 ubiquitin-protein ligase NEDD4 NEDD4 Tchem Enzyme -2.44046 259.8 167
Ceramide glucosyltransferase UGCG Tclin Enzyme -2.17676 128.8 135
Peroxiredoxin-6 PRDX6 Tbio Non-IDG -2.63290 435.3 425
ATP-sensitive inward rectifier potassium channel 8 KCNJ8 Tbio Ion Channel -2.31405 197.3 142
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.96497 9525.3 1195
DNA-binding protein inhibitor ID-1 ID1 Tbio Transcription Factor -2.62261 440.3 311
DNA-binding protein inhibitor ID-3 ID3 Tbio Transcription Factor -2.36130 229.3 402
Fractalkine CX3CL1 Tbio Non-IDG -2.75789 636.6 518