Development Level

Tbio 115 | 11,651
Tclin 32 | 612
Tchem 21 | 1,388
Tdark 2 | 6,593

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 27 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal bone structure 5 | 187
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased bone mineral density 4 | 126
decreased total body fat amoun... 4 | 207
increased bone mineral content 4 | 108
increased heart weight 4 | 62
abnormal behavior 3 | 298
decreased lean body mass 3 | 135
increased circulating sodium l... 3 | 71
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased heart rate 2 | 18
decreased lactate dehydrogenas... 2 | 16
decreased startle reflex 2 | 75
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
prolonged RR interval 2 | 8
short tibia 2 | 97
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 10
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 3
abnormal maxilla morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
bleb 1 | 2
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
fused cornea and lens 1 | 5
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating total pr... 1 | 28
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Muscle Weakness 170 | 170
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 168 | 17,369
Skin and soft tissues 167 | 17,230
Urinary Tract 167 | 16,678
Blood and immune system 166 | 16,909
Endocrine System 166 | 18,159
Female tissues 166 | 17,400
Liver and Pancreas 166 | 16,750
Male tissues 166 | 17,142
Nervous System 163 | 16,725
Respiratory system 163 | 16,393
Cardiovascular System 156 | 15,192

Target Family

Enzyme 68 | 4,145
Non-IDG 65 | 12,091
Kinase 11 | 634
Transporter 8 | 473
Ion Channel 7 | 344
Transcription Factor 7 | 1,400
Epigenetic 2 | 242
GPCR 2 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 NDUFAF3 Tclin Enzyme -2.16371 139.2 56
Mannose-1-phosphate guanyltransferase beta GMPPB Tbio Enzyme -1.17283 16.0 118