Development Level

Tbio 99 | 11,178
Tchem 36 | 1,885
Tclin 31 | 612
Tdark 2 | 6,569

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 27 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal bone structure 5 | 187
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased bone mineral density 4 | 126
decreased total body fat amoun... 4 | 207
increased bone mineral content 4 | 108
increased heart weight 4 | 62
abnormal behavior 3 | 298
decreased lean body mass 3 | 135
increased circulating sodium l... 3 | 71
preweaning lethality, incomple... 3 | 499
abnormal heart morphology 2 | 162
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased heart rate 2 | 18
decreased lactate dehydrogenas... 2 | 16
decreased startle reflex 2 | 75
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
prolonged RR interval 2 | 8
short tibia 2 | 97
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 10
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 3
abnormal maxilla morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
bleb 1 | 2
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
fused cornea and lens 1 | 5
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating total pr... 1 | 28
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Muscle Weakness 168 | 168
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Digestive Tract 166 | 17,369
Skin and soft tissues 165 | 17,230
Urinary Tract 165 | 16,678
Blood and immune system 164 | 16,909
Endocrine System 164 | 18,159
Female tissues 164 | 17,400
Liver and Pancreas 164 | 16,750
Male tissues 164 | 17,142
Nervous System 161 | 16,725
Respiratory system 161 | 16,393
Cardiovascular System 154 | 15,192

Target Family

Enzyme 66 | 4,145
Non-IDG 65 | 12,091
Kinase 11 | 634
Transporter 8 | 473
Ion Channel 7 | 344
Transcription Factor 7 | 1,400
Epigenetic 2 | 242
GPCR 2 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Ras GTPase-activating protein 2 RASA2 Tdark Enzyme -0.99879 9.85 24
Pro-thyrotropin-releasing hormone TRH Tbio Non-IDG -3.25312 1828.2 102
Frataxin, mitochondrial FXN Tbio Non-IDG -3.02739 1114.8 403
Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A Tchem Ion Channel -3.06226 1140.1 64
Alpha-N-acetylgalactosaminidase NAGA Tbio Enzyme -2.21917 159.3 96
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 Tclin Enzyme -1.48141 29.4 191
Fibroblast growth factor 23 FGF23 Tchem Non-IDG -3.19500 1726.4 296
DNA excision repair protein ERCC-6 ERCC6 Tbio Non-IDG -2.31776 361.5 163
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B Tclin Enzyme -2.10107 125.6 114