Development Level

Tbio 953 | 10,625
Tchem 161 | 1,890
Tdark 138 | 7,003
Tclin 75 | 602

Collection

Eligible Kinase Proteins 7 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 80 | 633
embryonic lethality prior to o... 23 | 148
preweaning lethality, incomple... 21 | 260
embryonic lethality prior to t... 20 | 187
decreased body weight 16 | 174
decreased lean body mass 14 | 195
decreased total body fat amoun... 13 | 186
abnormal retina morphology 11 | 100
decreased bone mineral content 11 | 157
prenatal lethality prior to he... 11 | 64
abnormal behavior 10 | 226
abnormal embryo size 9 | 112
abnormal lens morphology 9 | 73
decreased body length 9 | 108
decreased bone mineral density 9 | 126
increased or absent threshold ... 9 | 128
decreased circulating triglyce... 8 | 83
hypoactivity 8 | 89
decreased effector memory CD8-... 7 | 24
decreased rib number 7 | 59
increased circulating HDL chol... 7 | 63
increased circulating alkaline... 7 | 119
increased circulating choleste... 7 | 53
increased fasted circulating g... 7 | 68
increased lean body mass 7 | 107
male infertility 7 | 62
decreased grip strength 6 | 123
increased bone mineral content 6 | 92
increased grip strength 6 | 83
cataract 5 | 26
decreased CD4-positive, CD25-p... 5 | 24
decreased CD4-positive, alpha ... 5 | 19
decreased T cell number 5 | 31
decreased leukocyte cell numbe... 5 | 54
decreased lumbar vertebrae num... 5 | 62
enlarged heart 5 | 111
increased mean corpuscular hem... 5 | 93
increased rib number 5 | 41
increased sacral vertebrae num... 5 | 62
thrombocytopenia 5 | 46
abnormal bone structure 4 | 131
abnormal cranium morphology 4 | 32
abnormal eye morphology 4 | 38
abnormal gait 4 | 51
abnormal skin coloration 4 | 18
decreased CD8-positive, alpha-... 4 | 26
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating chloride... 4 | 32
decreased circulating insulin ... 4 | 75
decreased circulating sodium l... 4 | 18
decreased heart weight 4 | 44
decreased total retina thickne... 4 | 20
enlarged lymph nodes 4 | 27
improved glucose tolerance 4 | 56
increased B cell number 4 | 23
increased body length 4 | 20
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
increased circulating glucose ... 4 | 16
increased exploration in new e... 4 | 56
increased leukocyte cell numbe... 4 | 37
shortened RR interval 4 | 19
abnormal coat/hair pigmentatio... 3 | 54
abnormal skin condition 3 | 6
abnormal skin morphology 3 | 23
abnormal sleep behavior 3 | 63
abnormal testis morphology 3 | 30
decreased NK T cell number 3 | 28
decreased alpha-beta T cell nu... 3 | 12
decreased blood urea nitrogen ... 3 | 31
decreased circulating LDL chol... 3 | 37
decreased circulating calcium ... 3 | 33
decreased circulating fructosa... 3 | 31
decreased circulating glucose ... 3 | 121
decreased fasted circulating g... 3 | 49
decreased gamma-delta T cell n... 3 | 18
decreased hemoglobin content 3 | 53
decreased mean corpuscular hem... 3 | 19
decreased neutrophil cell numb... 3 | 37
decreased startle reflex 3 | 48
embryonic growth retardation 3 | 28
female infertility 3 | 34
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased CD4-positive, CD25-p... 3 | 18
increased NK cell number 3 | 19
increased body weight 3 | 42
increased circulating calcium ... 3 | 32
increased circulating sodium l... 3 | 71
increased granulocyte number 3 | 8
increased heart weight 3 | 37
increased mean corpuscular vol... 3 | 91
increased prepulse inhibition 3 | 21
increased startle reflex 3 | 38
increased total body fat amoun... 3 | 57
pallor 3 | 13
small adrenal glands 3 | 15
small testis 3 | 37

Disease

Multiple myeloma 1,327 | 1,327
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 1,325 | 17,995
Endocrine System 1,324 | 18,512
Cardiovascular System 1,323 | 17,958
Female tissues 1,323 | 18,647
Liver and Pancreas 1,323 | 18,136
Nervous System 1,323 | 18,561
Digestive Tract 1,322 | 18,473
Male tissues 1,322 | 17,969
Urinary Tract 1,322 | 18,444
Respiratory system 1,320 | 17,484
Skin and soft tissues 1,316 | 18,115

Target Family

Non-IDG 766 | 11,971
Enzyme 407 | 4,146
Transcription Factor 55 | 1,400
Kinase 40 | 634
Epigenetic 25 | 242
Transporter 22 | 473
GPCR 4 | 406
Ion Channel 4 | 341
TF/Epigenetic 3 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612