Development Level

Tbio 351 | 11,651
Tclin 80 | 612
Tchem 68 | 1,388
Tdark 41 | 6,593

Collection

RFA-RM-18-021 19 | 328
Ion Channel: IDG Consortium (T... 16 | 99
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 12 | 298
decreased vertical activity 12 | 208
enlarged heart 11 | 210
embryonic lethality prior to t... 8 | 278
abnormal heart morphology 7 | 162
abnormal seminal vesicle morph... 7 | 114
hyperactivity 7 | 148
abnormal bone structure 6 | 187
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 126
decreased bone mineral content 5 | 151
decreased total body fat amoun... 5 | 207
embryonic lethality prior to o... 5 | 239
hypoactivity 5 | 132
increased lymphocyte cell numb... 5 | 32
short tibia 5 | 97
cataract 4 | 92
decreased circulating insulin ... 4 | 76
decreased erythrocyte cell num... 4 | 62
decreased mean corpuscular vol... 4 | 79
enlarged lymph nodes 4 | 37
increased circulating alkaline... 4 | 122
increased heart rate 4 | 23
increased mean corpuscular vol... 4 | 92
increased neutrophil cell numb... 4 | 46
increased total body fat amoun... 4 | 134
abnormal behavioral response t... 3 | 66
abnormal gait 3 | 69
abnormal lung morphology 3 | 26
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
decreased blood urea nitrogen ... 3 | 51
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
decreased startle reflex 3 | 75
enlarged uterus 3 | 11
increased eosinophil cell numb... 3 | 11
increased leukocyte cell numbe... 3 | 47
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
abnormal duodenum morphology 2 | 4
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal facial morphology 2 | 17
abnormal femur morphology 2 | 14
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 81
abnormal limb morphology 2 | 13
abnormal retina morphology 2 | 71
abnormal vertebrae morphology 2 | 18
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased fasted circulating g... 2 | 65
decreased heart rate variabili... 2 | 13
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
hemorrhage 2 | 23
hydrometra 2 | 53
impaired righting response 2 | 26
increased basophil cell number 2 | 7
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
prolonged ST segment 2 | 36
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal neural tube closure 1 | 46
convulsive seizures 1 | 13
increased circulating magnesiu... 1 | 10
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33

Disease

Multiple Sclerosis 540 | 540
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 495 | 18,159
Digestive Tract 488 | 17,369
Female tissues 483 | 17,400
Skin and soft tissues 481 | 17,230
Blood and immune system 478 | 16,909
Male tissues 478 | 17,142
Urinary Tract 472 | 16,678
Liver and Pancreas 471 | 16,750
Nervous System 467 | 16,725
Respiratory system 459 | 16,393
Cardiovascular System 437 | 15,192

Target Family

Non-IDG 322 | 12,091
Enzyme 83 | 4,145
Ion Channel 45 | 344
Transcription Factor 35 | 1,400
GPCR 27 | 408
Kinase 13 | 634
Transporter 6 | 473
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38
oGPCR 2 | 421
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Sperm flagellar protein 2 SPEF2 Tdark Non-IDG -1.20840 16.3 33
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Sphingosine 1-phosphate receptor 4 S1PR4 Tclin GPCR -1.78966 58.4 256
Integrin beta-7 ITGB7 Tclin Non-IDG -1.63572 38.4 374
E-selectin SELE Tchem Non-IDG -3.44926 2672.1 919