Development Level

Tbio 61 | 10,625
Tchem 7 | 1,890
Tdark 7 | 7,003
Tclin 4 | 602

IMPC Term

decreased body weight 4 | 174
preweaning lethality, complete... 4 | 633
abnormal coat/hair pigmentatio... 3 | 54
abnormal retina morphology 3 | 100
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
abnormal behavior 2 | 226
abnormal gait 2 | 51
embryonic lethality prior to t... 2 | 187
limb grasping 2 | 35
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal eye posterior chamber... 1 | 3
abnormal eyelid aperture 1 | 3
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta size 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal social/conspecific in... 1 | 3
absent vibrissae 1 | 14
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
craniofacial phenotype 1 | 9
decreased B cell number 1 | 30
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased effector memory T-he... 1 | 2
decreased erythrocyte cell num... 1 | 43
decreased exploration in new e... 1 | 9
decreased heart rate variabili... 1 | 11
decreased leukocyte cell numbe... 1 | 54
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
increased CD8-positive, alpha-... 1 | 11
increased CD8-positive, naive ... 1 | 3
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased coping response 1 | 3
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart rate 1 | 17
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
microcephaly 1 | 3
mydriasis 1 | 9
narrow eye opening 1 | 15
oligodactyly 1 | 14
shortened QT interval 1 | 4
shortened ST segment 1 | 9
small superior vagus ganglion 1 | 20
syndactyly 1 | 4

Disease

Microphthalmia 79 | 79
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 78 | 18,473
Endocrine System 78 | 18,512
Nervous System 78 | 18,561
Skin and soft tissues 78 | 18,115
Female tissues 77 | 18,647
Urinary Tract 76 | 18,444
Blood and immune system 75 | 17,995
Cardiovascular System 75 | 17,958
Male tissues 75 | 17,969
Liver and Pancreas 72 | 18,136
Respiratory system 70 | 17,484

Target Family

Non-IDG 30 | 11,969
Transcription Factor 26 | 1,400
Enzyme 17 | 4,146
Epigenetic 2 | 242
Transporter 2 | 473
Kinase 1 | 634
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tchem Enzyme -2.93891 844.0 215
L-dopachrome tautomerase DCT Tbio Enzyme -2.27930 155.5 253
Retinal homeobox protein Rx RAX Tbio Transcription Factor -0.52554 4.68 196
Forkhead box protein E3 FOXE3 Tbio Transcription Factor -1.47957 27.9 138
Double-stranded RNA-binding protein Staufen homolog 2 STAU2 Tbio Non-IDG -1.18896 18.8 168
Cat eye syndrome critical region protein 2 CECR2 Tchem Epigenetic -2.16064 142.8 42
Membrane frizzled-related protein MFRP Tbio Non-IDG -2.03056 58.2 162
Beta-crystallin A4 CRYBA4 Tbio Non-IDG -1.22265 13.8 87
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.03044 1092.0 356
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.66256 471.8 306