Development Level

Tbio 203 | 11,445
Tchem 48 | 1,598
Tclin 18 | 613
Tdark 6 | 6,588

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 46 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 8 | 278
decreased body weight 7 | 161
preweaning lethality, incomple... 6 | 499
abnormal embryo size 5 | 220
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
enlarged heart 5 | 210
abnormal seminal vesicle morph... 4 | 114
decreased bone mineral content 4 | 151
decreased lean body mass 4 | 135
prenatal lethality prior to he... 4 | 87
abnormal joint morphology 3 | 23
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
increased bone mineral density 3 | 72
increased mean corpuscular hem... 3 | 96
increased total body fat amoun... 3 | 134
male infertility 3 | 123
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal brain morphology 2 | 13
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo development 2 | 7
abnormal facial morphology 2 | 17
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal snout morphology 2 | 23
abnormal tail morphology 2 | 25
brachydactyly 2 | 19
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
enlarged lymph nodes 2 | 37
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
prenatal lethality 2 | 28
small superior vagus ganglion 2 | 74
syndactyly 2 | 23
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
decreased IgG1 level 1 | 8
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
dilated heart left ventricle 1 | 11
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
limb grasping 1 | 41
long tibia 1 | 25
microphthalmia 1 | 26
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Micrognathism 275 | 275
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 272 | 18,159
Male tissues 272 | 17,142
Digestive Tract 271 | 17,369
Skin and soft tissues 271 | 17,230
Blood and immune system 269 | 16,909
Female tissues 268 | 17,400
Liver and Pancreas 268 | 16,750
Urinary Tract 266 | 16,678
Nervous System 264 | 16,725
Respiratory system 264 | 16,393
Cardiovascular System 260 | 15,192

Target Family

Non-IDG 139 | 12,091
Enzyme 61 | 4,145
Kinase 28 | 634
Transcription Factor 26 | 1,400
Epigenetic 10 | 242
Ion Channel 4 | 344
GPCR 2 | 408
TF/Epigenetic 2 | 38
Transporter 2 | 473
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
B9 domain-containing protein 1 B9D1 Tdark Non-IDG -0.61316 3.72 43
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
WASH complex subunit 5 WASHC5 Tbio Non-IDG -1.43182 26.4 38
Fibrocystin PKHD1 Tbio Non-IDG -1.71770 56.1 82
Transducin beta-like protein 2 TBL2 Tbio Non-IDG -1.00878 10.8 139
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376