Development Level

Tbio 477 | 11,651
Tdark 94 | 6,593
Tchem 82 | 1,388
Tclin 58 | 612

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 12 | 298
decreased total body fat amoun... 12 | 207
embryonic lethality prior to t... 12 | 278
enlarged heart 11 | 210
increased startle reflex 11 | 112
abnormal embryo size 9 | 220
abnormal heart morphology 9 | 162
decreased body weight 9 | 161
increased lean body mass 9 | 172
increased total body fat amoun... 9 | 134
abnormal gait 8 | 69
abnormal seminal vesicle morph... 8 | 114
decreased vertical activity 8 | 208
embryonic lethality prior to o... 8 | 239
small superior vagus ganglion 8 | 74
abnormal bone structure 7 | 187
decreased hemoglobin content 7 | 68
decreased lymphocyte cell numb... 7 | 83
increased or absent threshold ... 7 | 101
abnormal sleep behavior 6 | 70
decreased circulating serum al... 6 | 82
decreased erythrocyte cell num... 6 | 62
decreased prepulse inhibition 6 | 82
decreased startle reflex 6 | 75
limb grasping 6 | 41
male infertility 6 | 123
abnormal retina morphology 5 | 71
cataract 5 | 92
decreased bone mineral density 5 | 126
decreased circulating iron lev... 5 | 32
decreased hematocrit 5 | 46
hyperactivity 5 | 148
hypoactivity 5 | 132
increased monocyte cell number 5 | 63
short tibia 5 | 97
abnormal behavioral response t... 4 | 66
abnormal lens morphology 4 | 81
decreased bone mineral content 4 | 151
decreased circulating aspartat... 4 | 34
decreased circulating choleste... 4 | 93
decreased exploration in new e... 4 | 11
decreased lean body mass 4 | 135
decreased leukocyte cell numbe... 4 | 73
edema 4 | 59
embryonic growth retardation 4 | 106
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
increased blood urea nitrogen ... 4 | 48
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
increased neutrophil cell numb... 4 | 46
persistence of hyaloid vascula... 4 | 33
prolonged QT interval 4 | 38
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal epididymis morphology 3 | 42
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal locomotor activation 3 | 16
abnormal neural tube closure 3 | 46
abnormal skin morphology 3 | 50
abnormal startle reflex 3 | 15
absent startle reflex 3 | 24
brachydactyly 3 | 19
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
decreased circulating amylase ... 3 | 28
decreased circulating glucose ... 3 | 126
decreased circulating total pr... 3 | 49
decreased circulating triglyce... 3 | 79
decreased eosinophil cell numb... 3 | 24
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
decreased red blood cell distr... 3 | 41
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating amylase ... 3 | 25
increased circulating choleste... 3 | 66
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
prolonged QRS complex duration 3 | 8
syndactyly 3 | 23
decreased caudal vertebrae num... 2 | 53
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased mean corpuscular hem... 2 | 31
decreased neutrophil cell numb... 2 | 42
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45

Disease

Melanoma 711 | 711
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 682 | 18,159
Female tissues 657 | 17,400
Digestive Tract 650 | 17,369
Male tissues 639 | 17,142
Skin and soft tissues 635 | 17,230
Urinary Tract 622 | 16,678
Liver and Pancreas 616 | 16,750
Nervous System 608 | 16,725
Blood and immune system 607 | 16,909
Respiratory system 594 | 16,393
Cardiovascular System 526 | 15,192

Target Family

Non-IDG 397 | 12,091
Enzyme 145 | 4,145
Kinase 41 | 634
Ion Channel 31 | 344
Transcription Factor 31 | 1,400
Transporter 27 | 473
GPCR 19 | 408
Epigenetic 12 | 242
TF/Epigenetic 3 | 38
oGPCR 3 | 421
Nuclear Receptor 2 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Teashirt homolog 2 TSHZ2 Tbio Non-IDG -0.01649 0.78 90
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227