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Target Filters...

Development Level

Tbio 90 | 11,651
Tchem 31 | 1,388
Tclin 14 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
decreased vertical activity 5 | 208
preweaning lethality, complete... 5 | 979
hyperactivity 4 | 148
abnormal behavior 3 | 298
abnormal retina morphology 3 | 71
decreased circulating serum al... 3 | 82
embryonic lethality prior to t... 3 | 278
increased circulating alkaline... 3 | 122
abnormal epididymis morphology 2 | 42
abnormal kidney morphology 2 | 65
abnormal skin morphology 2 | 50
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
increased circulating choleste... 2 | 66
increased circulating total pr... 2 | 28
increased startle reflex 2 | 112
short tibia 2 | 97
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal locomotor behavior 1 | 24
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged seminal vesicle 1 | 10
enlarged spleen 1 | 41
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased IgA level 1 | 1
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
microphthalmia 1 | 26
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38

Disease

Mammary Neoplasms, Animal 136 | 136
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Female tissues 135 | 17,400
Male tissues 135 | 17,142
Digestive Tract 134 | 17,369
Endocrine System 134 | 18,159
Skin and soft tissues 134 | 17,230
Blood and immune system 132 | 16,909
Urinary Tract 132 | 16,678
Liver and Pancreas 131 | 16,750
Respiratory system 130 | 16,393
Nervous System 128 | 16,725
Cardiovascular System 126 | 15,192

Target Family

Non-IDG 82 | 12,091
Enzyme 29 | 4,145
Kinase 8 | 634
Transcription Factor 8 | 1,400
Nuclear Receptor 4 | 48
GPCR 2 | 408
Transporter 2 | 473
Ion Channel 1 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
TSC22 domain family protein 1 TSC22D1 Tbio Transcription Factor -1.54599 46.0 300
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Beta-casein CSN2 Tbio Enzyme -3.21413 1579.5 110
CD166 antigen ALCAM Tbio Non-IDG -2.49297 326.4 492
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Lipolysis-stimulated lipoprotein receptor LSR Tbio Non-IDG -1.92670 81.8 89
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.58528 37.8 68