Development Level

Tbio 255 | 11,651
Tchem 103 | 1,388
Tclin 53 | 612
Tdark 14 | 6,593

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 15 | 499
embryonic lethality prior to t... 13 | 278
decreased vertical activity 12 | 208
embryonic lethality prior to o... 12 | 239
increased total body fat amoun... 10 | 134
abnormal behavior 9 | 298
decreased bone mineral density 7 | 126
increased circulating HDL chol... 7 | 80
abnormal embryo size 6 | 220
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
hypoactivity 6 | 132
increased lean body mass 6 | 172
abnormal lens morphology 5 | 81
cataract 5 | 92
decreased body weight 5 | 161
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
enlarged heart 5 | 210
increased bone mineral content 5 | 108
increased circulating choleste... 5 | 66
increased mean corpuscular vol... 5 | 92
increased startle reflex 5 | 112
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
abnormal retina morphology 4 | 71
decreased circulating choleste... 4 | 93
decreased circulating iron lev... 4 | 32
decreased circulating triglyce... 4 | 79
decreased mean corpuscular vol... 4 | 79
hyperactivity 4 | 148
increased blood urea nitrogen ... 4 | 48
increased circulating alkaline... 4 | 122
abnormal bone mineralization 3 | 38
abnormal sleep behavior 3 | 70
abnormal startle reflex 3 | 15
abnormal tail movements 3 | 12
abnormal vocalization 3 | 21
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased erythrocyte cell num... 3 | 62
decreased heart weight 3 | 27
decreased prepulse inhibition 3 | 82
embryonic growth retardation 3 | 106
increased bone mineral density 3 | 72
increased circulating iron lev... 3 | 30
increased circulating potassiu... 3 | 29
increased grip strength 3 | 41
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
prolonged QRS complex duration 3 | 8
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
short tibia 3 | 97
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal head morphology 2 | 10
abnormal locomotor behavior 2 | 24
abnormal lung morphology 2 | 26
abnormal spleen morphology 2 | 55
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased grip strength 2 | 116
decreased hemoglobin content 2 | 68
decreased lactate dehydrogenas... 2 | 16
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
hemorrhage 2 | 23
hydrometra 2 | 53
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased body temperature 2 | 9
increased circulating alanine ... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
male infertility 2 | 123
mammalian phenotype 2 | 17
persistence of hyaloid vascula... 2 | 33
small spleen 2 | 19
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal optic disc morphology 1 | 10

Disease

Mammary Neoplasms 425 | 425
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 419 | 18,159
Female tissues 418 | 17,400
Skin and soft tissues 417 | 17,230
Digestive Tract 416 | 17,369
Urinary Tract 416 | 16,678
Blood and immune system 413 | 16,909
Liver and Pancreas 413 | 16,750
Male tissues 413 | 17,142
Nervous System 407 | 16,725
Respiratory system 406 | 16,393
Cardiovascular System 382 | 15,192

Target Family

Non-IDG 222 | 12,091
Enzyme 88 | 4,145
Transcription Factor 41 | 1,400
Kinase 31 | 634
Transporter 12 | 473
Nuclear Receptor 11 | 48
Epigenetic 9 | 242
GPCR 7 | 408
Ion Channel 2 | 344
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275