Development Level

Tbio 221 | 10,625
Tchem 122 | 1,890
Tclin 51 | 602
Tdark 16 | 7,003

IMPC Phenotype

preweaning lethality, complete... 21 | 633
decreased lean body mass 9 | 195
decreased grip strength 8 | 123
preweaning lethality, incomple... 8 | 260
decreased body weight 7 | 174
embryonic lethality prior to t... 6 | 187
increased circulating HDL chol... 6 | 63
increased grip strength 6 | 83
increased mean corpuscular vol... 6 | 91
abnormal behavior 5 | 226
abnormal bone mineralization 5 | 55
decreased body length 5 | 108
decreased bone mineral density 5 | 126
increased circulating choleste... 5 | 53
increased total body fat amoun... 5 | 57
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
abnormal lens morphology 4 | 73
abnormal retina morphology 4 | 100
decreased bone mineral content 4 | 157
decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
decreased circulating iron lev... 4 | 25
decreased fasted circulating g... 4 | 49
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
abnormal iris morphology 3 | 12
abnormal startle reflex 3 | 14
decreased circulating triglyce... 3 | 83
decreased prepulse inhibition 3 | 52
embryonic lethality prior to o... 3 | 148
increased blood urea nitrogen ... 3 | 44
increased circulating potassiu... 3 | 31
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
short tibia 3 | 82
abnormal coat-hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal head morphology 2 | 10
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal tail movements 2 | 12
abnormal tooth morphology 2 | 24
cataract 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased erythrocyte cell num... 2 | 43
decreased hemoglobin content 2 | 53
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
enlarged kidney 2 | 7
hyperactivity 2 | 108
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating alanine ... 2 | 11
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased respiratory quotient 2 | 12
increased sacral vertebrae num... 2 | 62
irregularly shaped pupil 2 | 7
male infertility 2 | 62
narrow eye opening 2 | 15
thrombocytopenia 2 | 46
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal retinal inner nuclear... 1 | 5
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
decreased T cell number 1 | 31
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased pulmonary respirator... 1 | 4
decreased total retina thickne... 1 | 20
female infertility 1 | 34
increased blood uric acid leve... 1 | 5
lethargy 1 | 5
persistence of hyaloid vascula... 1 | 22
straub tail 1 | 26
tremors 1 | 34

Disease

Mammary Neoplasms 410 | 410
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 409 | 18,560
Blood and immune system 408 | 17,994
Digestive Tract 407 | 18,472
Endocrine System 407 | 18,511
Female tissues 407 | 18,646
Liver and Pancreas 406 | 18,135
Skin and soft tissues 406 | 18,114
Urinary Tract 406 | 18,443
Cardiovascular System 404 | 17,957
Male tissues 404 | 17,968
Respiratory system 399 | 17,483

Target Family

Non-IDG 213 | 11,969
Enzyme 85 | 4,146
Transcription Factor 40 | 1,400
Kinase 30 | 634
Transporter 12 | 473
Nuclear Receptor 11 | 48
Epigenetic 9 | 242
GPCR 6 | 408
Ion Channel 2 | 341
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
LIM domain-containing protein 2 LIMD2 Tdark Non-IDG -0.89117 2.22 53
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806
A-kinase anchor protein 12 AKAP12 Tbio Enzyme -1.97288 119.1 151
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.58936 5.14 132
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.60310 374.7 140
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
DNA repair protein XRCC2 XRCC2 Tbio Non-IDG -2.73754 465.9 235
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.49911 286.4 377
EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 Tbio Non-IDG -2.12889 148.3 205