Development Level

Tbio 89 | 11,651
Tclin 11 | 612
Tchem 7 | 1,388
Tdark 3 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased body weight 5 | 161
decreased total body fat amoun... 4 | 207
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
decreased circulating HDL chol... 3 | 68
decreased circulating alanine ... 3 | 47
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
embryonic lethality prior to t... 3 | 278
hydrometra 3 | 53
male infertility 3 | 123
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal snout morphology 2 | 23
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal nail morphology 1 | 8
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
cystolithiasis 1 | 3
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased lumbar vertebrae num... 1 | 2
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
enlarged urinary bladder 1 | 8
enlarged uterus 1 | 11
excessive tearing 1 | 2
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
limb grasping 1 | 41
microphthalmia 1 | 26
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
short tibia 1 | 97
small epididymis 1 | 3
small kidney 1 | 16
small seminal vesicle 1 | 10
urinary bladder obstruction 1 | 4

Disease

Low-set, posteriorly rotated ears 110 | 110
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 109 | 18,159
Male tissues 109 | 17,142
Female tissues 107 | 17,400
Nervous System 107 | 16,725
Skin and soft tissues 107 | 17,230
Urinary Tract 107 | 16,678
Blood and immune system 106 | 16,909
Digestive Tract 106 | 17,369
Liver and Pancreas 106 | 16,750
Respiratory system 106 | 16,393
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 54 | 12,091
Enzyme 25 | 4,145
Transcription Factor 12 | 1,400
Kinase 10 | 634
Epigenetic 4 | 242
Ion Channel 2 | 344
Transporter 2 | 473
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
T-cell surface protein tactile CD96 Tbio Non-IDG -2.05505 111.7 205
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.88065 80.4 419
Histone acetyltransferase KAT6B KAT6B Tbio Epigenetic -2.30232 201.0 58
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
Protein cereblon CRBN Tclin Non-IDG -2.33306 211.0 82
Semaphorin-3E SEMA3E Tbio Non-IDG -1.62878 48.9 219
Nipped-B-like protein NIPBL Tbio Non-IDG -2.25874 186.3 134
LIM domain kinase 1 LIMK1 Tchem Kinase -2.28919 187.7 664