Development Level

Tbio 137 | 11,445
Tchem 28 | 1,598
Tclin 14 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 30 | 979
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to o... 8 | 239
abnormal embryo size 6 | 220
abnormal behavior 4 | 298
embryonic lethality prior to t... 4 | 278
prenatal lethality prior to he... 4 | 87
abnormal lens morphology 3 | 81
cataract 3 | 92
embryonic growth retardation 3 | 106
hydrometra 3 | 53
hyperactivity 3 | 148
hypoactivity 3 | 132
increased lean body mass 3 | 172
small superior vagus ganglion 3 | 74
abnormal craniofacial morpholo... 2 | 33
abnormal gait 2 | 69
abnormal locomotor behavior 2 | 24
abnormal retinal vasculature m... 2 | 27
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
enlarged lymph nodes 2 | 37
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased mean corpuscular hem... 2 | 96
microphthalmia 2 | 26
premature death 2 | 5
prenatal lethality 2 | 28
small testis 2 | 58
abnormal brain morphology 1 | 13
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal spinal cord morpholog... 1 | 9
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased pulmonary respirator... 1 | 5
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
enlarged kidney 1 | 14
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
long tibia 1 | 25
pallor 1 | 34
short tibia 1 | 97
shortened QT interval 1 | 4
small kidney 1 | 16
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Low set ears 181 | 181
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 179 | 18,159
Digestive Tract 178 | 17,369
Male tissues 178 | 17,142
Skin and soft tissues 178 | 17,230
Female tissues 176 | 17,400
Nervous System 175 | 16,725
Blood and immune system 174 | 16,909
Liver and Pancreas 173 | 16,750
Urinary Tract 173 | 16,678
Respiratory system 171 | 16,393
Cardiovascular System 167 | 15,192

Target Family

Non-IDG 86 | 12,091
Enzyme 44 | 4,145
Transcription Factor 25 | 1,400
Kinase 12 | 634
Epigenetic 8 | 242
Ion Channel 4 | 344
GPCR 2 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2 Tbio Non-IDG -1.67314 52.3 243
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.68609 492.0 349
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Nuclear factor 1 X-type NFIX Tbio Transcription Factor -1.70265 49.7 74
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
Glutamate receptor-interacting protein 1 GRIP1 Tbio Non-IDG -2.18570 152.7 157