Development Level

Tbio 388 | 11,445
Tdark 101 | 6,588
Tchem 75 | 1,598
Tclin 40 | 613

Collection

Kinase: IDG Consortium (Target... 8 | 125
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Targets) 4 | 126
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 43 | 979
preweaning lethality, incomple... 17 | 499
embryonic lethality prior to t... 12 | 278
abnormal bone structure 11 | 187
abnormal embryo size 11 | 220
increased startle reflex 11 | 112
abnormal retina morphology 7 | 71
decreased lean body mass 7 | 135
decreased lymphocyte cell numb... 7 | 83
decreased mean corpuscular vol... 7 | 79
decreased total body fat amoun... 7 | 207
enlarged heart 7 | 210
increased heart weight 7 | 62
increased lean body mass 7 | 172
increased total body fat amoun... 7 | 134
abnormal behavior 6 | 298
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
decreased circulating choleste... 6 | 93
decreased grip strength 6 | 116
decreased vertical activity 6 | 208
impaired glucose tolerance 6 | 75
improved glucose tolerance 6 | 79
increased circulating triglyce... 6 | 42
short tibia 6 | 97
abnormal coat-hair pigmentatio... 5 | 64
abnormal lens morphology 5 | 81
decreased bone mineral density 5 | 126
decreased prepulse inhibition 5 | 82
embryonic lethality prior to o... 5 | 239
hypoactivity 5 | 132
increased bone mineral density 5 | 72
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
increased circulating sodium l... 5 | 71
increased red blood cell distr... 5 | 34
male infertility 5 | 123
prenatal lethality prior to he... 5 | 87
abnormal cornea morphology 4 | 31
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
cataract 4 | 92
decreased body length 4 | 101
decreased circulating HDL chol... 4 | 68
decreased circulating alkaline... 4 | 46
decreased circulating glucose ... 4 | 126
decreased circulating serum al... 4 | 82
decreased red blood cell distr... 4 | 41
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
increased circulating chloride... 4 | 41
increased circulating choleste... 4 | 66
increased or absent threshold ... 4 | 101
abnormal coat appearance 3 | 31
abnormal craniofacial morpholo... 3 | 33
abnormal kidney morphology 3 | 65
abnormal locomotor behavior 3 | 24
abnormal pericardium morpholog... 3 | 26
abnormal spleen morphology 3 | 55
corneal opacity 3 | 32
decreased blood urea nitrogen ... 3 | 51
decreased circulating total pr... 3 | 49
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased hemoglobin content 3 | 68
edema 3 | 59
impaired pupillary reflex 3 | 26
increased body weight 3 | 25
increased bone mineral content 3 | 108
increased circulating amylase ... 3 | 25
increased grip strength 3 | 41
increased monocyte cell number 3 | 63
mydriasis 3 | 6
persistence of hyaloid vascula... 3 | 33
small testis 3 | 58
tremors 3 | 39
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 46
abnormal optic disc morphology 2 | 10
abnormal placenta size 2 | 20
cardiovascular system phenotyp... 2 | 36
decreased circulating amylase ... 2 | 28
decreased circulating free fat... 2 | 31
decreased fasted circulating g... 2 | 65
decreased lactate dehydrogenas... 2 | 16
decreased neutrophil cell numb... 2 | 42
decreased pulmonary respirator... 2 | 5
enlarged spleen 2 | 41
enlarged stomach 2 | 2
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased hematocrit 2 | 46
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
pallor 2 | 34
small thymus 2 | 16

Disease

Liver cancer 604 | 604
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 586 | 18,159
Female tissues 565 | 17,400
Digestive Tract 558 | 17,369
Skin and soft tissues 556 | 17,230
Male tissues 555 | 17,142
Nervous System 545 | 16,725
Urinary Tract 536 | 16,678
Liver and Pancreas 534 | 16,750
Respiratory system 534 | 16,393
Blood and immune system 529 | 16,909
Cardiovascular System 479 | 15,192

Target Family

Non-IDG 368 | 12,091
Enzyme 70 | 4,145
Kinase 41 | 634
Ion Channel 32 | 344
Transcription Factor 31 | 1,400
Epigenetic 25 | 242
Transporter 19 | 473
GPCR 15 | 408
oGPCR 2 | 421
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protocadherin-15 PCDH15 Tbio Non-IDG -1.83877 74.3 42
Zinc finger protein 804B ZNF804B Tdark Non-IDG -0.10075 1.01 14
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
NACHT, LRR and PYD domains-containing protein 7 NLRP7 Tbio Non-IDG -1.63951 0.00000 84
Mucin-16 MUC16 Tbio Non-IDG -2.09951 138.4 0
Junctophilin-3 JPH3 Tbio Non-IDG -1.51901 34.8 165
Nesprin-2 SYNE2 Tbio Non-IDG -2.62747 380.6 39
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
VPS10 domain-containing receptor SorCS1 SORCS1 Tbio Non-IDG -1.36030 24.0 81
Extracellular matrix protein FRAS1 FRAS1 Tbio Non-IDG -1.51346 36.5 22