Development Level

Tbio 529 | 11,651
Tchem 119 | 1,388
Tdark 69 | 6,593
Tclin 52 | 612

Collection

RFA-RM-18-021 4 | 328
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 29 | 499
preweaning lethality, complete... 28 | 979
abnormal behavior 15 | 298
enlarged heart 13 | 210
decreased grip strength 10 | 116
decreased total body fat amoun... 10 | 207
decreased vertical activity 10 | 208
abnormal heart morphology 9 | 162
decreased body weight 9 | 161
decreased circulating glucose ... 9 | 126
short tibia 9 | 97
abnormal seminal vesicle morph... 8 | 114
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 8 | 278
abnormal coat-hair pigmentatio... 7 | 64
abnormal lens morphology 7 | 81
cataract 7 | 92
decreased circulating HDL chol... 7 | 68
decreased circulating choleste... 7 | 93
abnormal retina morphology 6 | 71
decreased body length 6 | 101
decreased bone mineral content 6 | 151
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 135
hypoactivity 6 | 132
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
abnormal sleep behavior 5 | 70
decreased circulating aspartat... 5 | 34
decreased circulating triglyce... 5 | 79
decreased erythrocyte cell num... 5 | 62
edema 5 | 59
hyperactivity 5 | 148
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased circulating HDL chol... 5 | 80
increased fasted circulating g... 5 | 76
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 96
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal testis morphology 4 | 43
decreased blood urea nitrogen ... 4 | 51
decreased circulating LDL chol... 4 | 38
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
increased blood urea nitrogen ... 4 | 48
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
increased total body fat amoun... 4 | 134
small testis 4 | 58
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal lung morphology 3 | 26
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating chloride... 3 | 30
decreased circulating phosphat... 3 | 27
decreased circulating serum al... 3 | 82
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased red blood cell distr... 3 | 41
decreased threshold for audito... 3 | 26
embryonic growth retardation 3 | 106
enlarged lymph nodes 3 | 37
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased circulating creatini... 3 | 38
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 36
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
increased prepulse inhibition 3 | 32
increased startle reflex 3 | 112
male infertility 3 | 123
persistence of hyaloid vascula... 3 | 33
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
tremors 3 | 39
abnormal limb bud morphology 2 | 17
abnormal pancreas morphology 2 | 13
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
decreased circulating bilirubi... 2 | 19
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
enlarged spleen 2 | 41
impaired pupillary reflex 2 | 26
increased body weight 2 | 25
increased circulating chloride... 2 | 41
increased circulating phosphat... 2 | 26
increased hemoglobin content 2 | 45
pale liver 2 | 6
prenatal lethality prior to he... 2 | 87
thrombocytosis 2 | 27

Disease

Liver Cirrhosis, Experimental 769 | 769
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 758 | 18,159
Liver and Pancreas 758 | 16,750
Digestive Tract 755 | 17,369
Urinary Tract 753 | 16,678
Female tissues 751 | 17,400
Blood and immune system 747 | 16,909
Skin and soft tissues 747 | 17,230
Male tissues 745 | 17,142
Nervous System 740 | 16,725
Respiratory system 733 | 16,393
Cardiovascular System 709 | 15,192

Target Family

Non-IDG 436 | 12,091
Enzyme 218 | 4,145
Kinase 29 | 634
Transcription Factor 29 | 1,400
Transporter 28 | 473
GPCR 14 | 408
Ion Channel 9 | 344
Epigenetic 3 | 242
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Galectin-2 LGALS2 Tbio Non-IDG -1.12300 13.4 172
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
TSC22 domain family protein 1 TSC22D1 Tbio Transcription Factor -1.54599 46.0 300
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Pleckstrin homology domain-containing family B member 1 PLEKHB1 Tbio Non-IDG -1.88689 75.6 39
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355