Development Level

Tbio 227 | 10,625
Tchem 104 | 1,890
Tclin 50 | 602
Tdark 15 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
abnormal bone mineralization 6 | 55
abnormal bone structure 5 | 131
decreased body weight 5 | 174
decreased circulating choleste... 5 | 85
decreased circulating insulin ... 5 | 75
decreased circulating triglyce... 5 | 83
decreased hemoglobin content 5 | 53
increased circulating alkaline... 5 | 119
abnormal behavior 4 | 226
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased grip strength 4 | 123
decreased total body fat amoun... 4 | 186
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
increased blood urea nitrogen ... 4 | 44
increased circulating choleste... 4 | 53
increased heart weight 4 | 37
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating alkaline... 3 | 41
decreased circulating serum al... 3 | 79
decreased circulating total pr... 3 | 41
hypoactivity 3 | 89
increased bone mineral content 3 | 92
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating creatini... 3 | 29
increased circulating total pr... 3 | 20
increased hemoglobin content 3 | 45
preweaning lethality, incomple... 3 | 260
abnormal QRS complex 2 | 25
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal pelvic girdle bone mo... 2 | 11
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased circulating alanine ... 2 | 53
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
enlarged epididymis 2 | 27
enlarged heart 2 | 111
impaired glucose tolerance 2 | 52
impaired righting response 2 | 19
increased circulating LDL chol... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased circulating triglyce... 2 | 24
increased hematocrit 2 | 36
increased monocyte cell number 2 | 27
irregularly shaped pupil 2 | 7
persistence of hyaloid vascula... 2 | 22
thrombocytopenia 2 | 46
trunk curl 2 | 15
abnormal behavioral response t... 1 | 52
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 30
abnormal lung morphology 1 | 15
abnormal testis morphology 1 | 30
decreased NK cell number 1 | 16
decreased body length 1 | 108
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased red blood cell distr... 1 | 11
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18
increased NK cell number 1 | 19
increased bone mineral density 1 | 52
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
long tibia 1 | 13
short tibia 1 | 82
stereotypic behavior 1 | 3
tremors 1 | 34
vertebral fusion 1 | 23

Disease

Kidney disease 396 | 396
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 372 | 18,561
Urinary Tract 372 | 18,444
Digestive Tract 371 | 18,473
Female tissues 371 | 18,647
Endocrine System 370 | 18,512
Liver and Pancreas 368 | 18,136
Blood and immune system 366 | 17,995
Cardiovascular System 366 | 17,958
Skin and soft tissues 364 | 18,115
Male tissues 363 | 17,969
Respiratory system 358 | 17,484

Target Family

Non-IDG 234 | 11,971
Enzyme 82 | 4,146
Transcription Factor 24 | 1,400
Kinase 17 | 634
Transporter 15 | 473
Ion Channel 10 | 341
GPCR 8 | 406
Nuclear Receptor 4 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Properdin CFP Tbio Non-IDG -3.16935 1491.5 297
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Apolipoprotein A-II APOA2 Tbio Non-IDG -2.80284 593.9 352