Development Level

Tbio 277 | 11,651
Tchem 88 | 1,388
Tclin 51 | 612
Tdark 14 | 6,593

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 22 | 979
decreased vertical activity 9 | 208
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 7 | 278
enlarged heart 7 | 210
abnormal heart morphology 6 | 162
increased mean corpuscular hem... 6 | 96
increased startle reflex 6 | 112
abnormal behavior 5 | 298
decreased erythrocyte cell num... 5 | 62
hypoactivity 5 | 132
increased bone mineral content 5 | 108
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
increased heart weight 5 | 62
increased total body fat amoun... 5 | 134
prolonged ST segment 5 | 36
small superior vagus ganglion 5 | 74
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal seminal vesicle morph... 4 | 114
decreased circulating HDL chol... 4 | 68
decreased circulating LDL chol... 4 | 38
decreased circulating alkaline... 4 | 46
decreased circulating choleste... 4 | 93
decreased circulating insulin ... 4 | 76
decreased circulating total pr... 4 | 49
decreased hemoglobin content 4 | 68
decreased mean corpuscular vol... 4 | 79
decreased total body fat amoun... 4 | 207
increased blood urea nitrogen ... 4 | 48
increased circulating creatini... 4 | 38
abnormal lens morphology 3 | 81
abnormal lung morphology 3 | 26
abnormal testis morphology 3 | 43
decreased body weight 3 | 161
decreased circulating amylase ... 3 | 28
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
enlarged uterus 3 | 11
improved glucose tolerance 3 | 79
increased circulating calcium ... 3 | 34
increased circulating chloride... 3 | 41
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
short tibia 3 | 97
small testis 3 | 58
abnormal bone mineralization 2 | 38
abnormal femur morphology 2 | 14
abnormal kidney morphology 2 | 65
abnormal pelvic girdle bone mo... 2 | 12
abnormal startle reflex 2 | 15
decreased T cell number 2 | 15
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased large unstained cell... 2 | 11
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating amylase ... 2 | 25
increased circulating bilirubi... 2 | 16
increased circulating potassiu... 2 | 29
increased circulating serum al... 2 | 22
increased eosinophil cell numb... 2 | 11
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased large unstained cell... 2 | 5
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
prolonged QT interval 2 | 38
thrombocytopenia 2 | 56
vertebral fusion 2 | 23
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal vibrissa morphology 1 | 25
decreased circulating calcium ... 1 | 36
decreased hematocrit 1 | 46
increased body weight 1 | 25
increased fasted circulating g... 1 | 76

Disease

Kidney disease 430 | 430
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 389 | 18,159
Digestive Tract 388 | 17,369
Urinary Tract 388 | 16,678
Skin and soft tissues 382 | 17,230
Male tissues 379 | 17,142
Liver and Pancreas 377 | 16,750
Female tissues 376 | 17,400
Blood and immune system 370 | 16,909
Nervous System 369 | 16,725
Respiratory system 359 | 16,393
Cardiovascular System 324 | 15,192

Target Family

Non-IDG 256 | 12,091
Enzyme 89 | 4,145
Transcription Factor 24 | 1,400
Kinase 17 | 634
Transporter 17 | 473
Ion Channel 12 | 344
GPCR 8 | 408
Nuclear Receptor 5 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275