Development Level

Tbio 1,719 | 11,651
Tdark 477 | 6,593
Tchem 256 | 1,388
Tclin 161 | 612

Collection

RFA-RM-18-021 45 | 328
Kinase: IDG Consortium (Target... 19 | 125
Ion Channel: IDG Consortium (T... 15 | 99
GPCR: IDG Consortium (Targets) 14 | 126
Kinase: IDG Consortium (Comple... 12 | 37
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 174 | 979
preweaning lethality, incomple... 91 | 499
embryonic lethality prior to t... 52 | 278
abnormal behavior 50 | 298
decreased total body fat amoun... 45 | 207
abnormal embryo size 43 | 220
embryonic lethality prior to o... 41 | 239
decreased body weight 40 | 161
abnormal bone structure 34 | 187
hypoactivity 30 | 132
increased lean body mass 30 | 172
enlarged heart 29 | 210
increased total body fat amoun... 28 | 134
decreased circulating choleste... 27 | 93
decreased grip strength 27 | 116
decreased lean body mass 27 | 135
decreased bone mineral content 26 | 151
increased startle reflex 26 | 112
decreased circulating glucose ... 24 | 126
decreased body length 23 | 101
hyperactivity 23 | 148
impaired glucose tolerance 23 | 75
decreased vertical activity 22 | 208
male infertility 22 | 123
increased bone mineral content 21 | 108
decreased bone mineral density 20 | 126
decreased lymphocyte cell numb... 20 | 83
embryonic growth retardation 19 | 106
increased mean corpuscular hem... 18 | 96
abnormal heart morphology 17 | 162
decreased circulating HDL chol... 17 | 68
decreased circulating serum al... 17 | 82
decreased prepulse inhibition 17 | 82
increased circulating alkaline... 17 | 122
increased or absent threshold ... 17 | 101
short tibia 17 | 97
increased circulating choleste... 16 | 66
increased circulating sodium l... 16 | 71
increased heart weight 16 | 62
abnormal retina morphology 15 | 71
cataract 15 | 92
increased circulating HDL chol... 15 | 80
abnormal gait 14 | 69
decreased circulating alkaline... 14 | 46
decreased fasted circulating g... 14 | 65
decreased mean corpuscular vol... 14 | 79
decreased startle reflex 14 | 75
prenatal lethality prior to he... 14 | 87
abnormal behavioral response t... 13 | 66
abnormal eye morphology 13 | 68
abnormal seminal vesicle morph... 13 | 114
decreased circulating alanine ... 13 | 47
decreased leukocyte cell numbe... 13 | 73
improved glucose tolerance 13 | 79
increased circulating triglyce... 13 | 42
increased mean platelet volume 13 | 45
increased monocyte cell number 13 | 63
abnormal lens morphology 12 | 81
decreased circulating insulin ... 12 | 76
decreased hemoglobin content 12 | 68
limb grasping 12 | 41
abnormal coat-hair pigmentatio... 11 | 64
abnormal sleep behavior 11 | 70
decreased caudal vertebrae num... 11 | 53
decreased circulating total pr... 11 | 49
decreased circulating triglyce... 11 | 79
increased bone mineral density 11 | 72
increased circulating chloride... 11 | 41
increased red blood cell distr... 11 | 34
small testis 11 | 58
cardiovascular system phenotyp... 10 | 36
increased circulating amylase ... 10 | 25
increased erythrocyte cell num... 10 | 39
increased fasted circulating g... 10 | 76
increased mean corpuscular vol... 10 | 92
abnormal cornea morphology 9 | 31
abnormal cranium morphology 9 | 36
absent startle reflex 9 | 24
decreased circulating amylase ... 9 | 28
increased circulating calcium ... 9 | 34
persistence of hyaloid vascula... 9 | 33
prolonged QT interval 9 | 38
small superior vagus ganglion 9 | 74
thrombocytopenia 9 | 56
abnormal kidney morphology 8 | 65
abnormal locomotor behavior 8 | 24
abnormal maxilla morphology 8 | 17
abnormal neural tube closure 8 | 46
abnormal tooth morphology 8 | 24
decreased circulating calcium ... 8 | 36
decreased erythrocyte cell num... 8 | 62
decreased mean corpuscular hem... 8 | 50
decreased red blood cell distr... 8 | 41
edema 8 | 59
enlarged spleen 8 | 41
increased leukocyte cell numbe... 8 | 47
increased neutrophil cell numb... 8 | 46
prenatal lethality 8 | 28
abnormal skin morphology 7 | 50
prolonged ST segment 7 | 36

Disease

Kidney cancer 2,613 | 2,613
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 2,553 | 18,159
Female tissues 2,488 | 17,400
Digestive Tract 2,458 | 17,369
Skin and soft tissues 2,452 | 17,230
Male tissues 2,448 | 17,142
Nervous System 2,428 | 16,725
Urinary Tract 2,400 | 16,678
Liver and Pancreas 2,399 | 16,750
Blood and immune system 2,387 | 16,909
Respiratory system 2,356 | 16,393
Cardiovascular System 2,205 | 15,192

Target Family

Non-IDG 1,452 | 12,091
Enzyme 457 | 4,145
Transcription Factor 178 | 1,400
Kinase 170 | 634
Ion Channel 106 | 344
Transporter 84 | 473
Epigenetic 77 | 242
GPCR 57 | 408
TF/Epigenetic 16 | 38
oGPCR 10 | 421
Nuclear Receptor 6 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64