Development Level

Tbio 414 | 10,625
Tchem 75 | 1,890
Tdark 48 | 7,003
Tclin 36 | 602

Collection

Kinase: IDG Consortium (Complete/Control) 2 | 37
Kinase: IDG Consortium (Targets) 2 | 125
GPCR: IDG Consortium (Targets) 1 | 127
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

preweaning lethality, complete... 28 | 633
abnormal behavior 17 | 226
decreased lean body mass 17 | 195
decreased body weight 13 | 174
decreased grip strength 13 | 123
decreased bone mineral content 12 | 157
decreased body length 11 | 108
embryonic lethality prior to t... 11 | 187
preweaning lethality, incomple... 11 | 260
decreased circulating HDL chol... 10 | 77
decreased total body fat amoun... 10 | 186
increased or absent threshold ... 10 | 128
abnormal bone structure 9 | 131
embryonic lethality prior to o... 9 | 148
decreased bone mineral density 8 | 126
decreased circulating choleste... 8 | 85
increased lean body mass 7 | 107
short tibia 7 | 82
decreased circulating serum al... 6 | 79
impaired glucose tolerance 6 | 52
increased circulating alkaline... 6 | 119
thrombocytopenia 6 | 46
abnormal embryo size 5 | 112
decreased circulating alanine ... 5 | 53
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
hyperactivity 5 | 108
hypoactivity 5 | 89
increased circulating HDL chol... 5 | 63
increased grip strength 5 | 83
increased sacral vertebrae num... 5 | 62
abnormal cranium morphology 4 | 32
abnormal heart morphology 4 | 51
abnormal retina morphology 4 | 100
decreased caudal vertebrae num... 4 | 49
decreased circulating LDL chol... 4 | 37
decreased circulating insulin ... 4 | 75
decreased hemoglobin content 4 | 53
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular vol... 4 | 50
decreased startle reflex 4 | 48
enlarged heart 4 | 111
increased blood urea nitrogen ... 4 | 44
increased bone mineral content 4 | 92
increased circulating calcium ... 4 | 32
increased circulating serum al... 4 | 25
increased fasted circulating g... 4 | 68
increased total body fat amoun... 4 | 57
tremors 4 | 34
abnormal bone mineralization 3 | 55
abnormal gait 3 | 51
abnormal head morphology 3 | 10
abnormal lens morphology 3 | 73
abnormal neural tube closure 3 | 37
abnormal vitreous body morphol... 3 | 7
cardiovascular system phenotyp... 3 | 35
corneal opacity 3 | 25
decreased circulating alkaline... 3 | 41
decreased circulating aspartat... 3 | 27
decreased circulating fructosa... 3 | 31
decreased circulating total pr... 3 | 41
decreased circulating triglyce... 3 | 83
decreased effector memory CD8-... 3 | 24
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased mean platelet volume 3 | 12
decreased neutrophil cell numb... 3 | 37
decreased total retina thickne... 3 | 20
enlarged lymph nodes 3 | 27
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased prepulse inhibition 3 | 21
increased rib number 3 | 41
increased startle reflex 3 | 38
prenatal lethality prior to he... 3 | 64
abnormal behavioral response t... 2 | 52
abnormal heart left ventricle ... 2 | 20
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal retinal inner nuclear... 2 | 5
abnormal spleen morphology 2 | 36
abnormal tooth morphology 2 | 24
decreased Ly6C high monocyte n... 2 | 18
decreased circulating bilirubi... 2 | 14
decreased circulating potassiu... 2 | 17
decreased pulmonary respirator... 2 | 4
enlarged stomach 2 | 2
female infertility 2 | 34
increased erythrocyte cell num... 2 | 26
increased hemoglobin content 2 | 45
lethargy 2 | 5
small thymus 2 | 11
vertebral fusion 2 | 23

Disease

Intellectual disability 573 | 573
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 570 | 18,472
Nervous System 570 | 18,560
Blood and immune system 567 | 17,994
Liver and Pancreas 567 | 18,135
Male tissues 567 | 17,968
Female tissues 566 | 18,646
Urinary Tract 566 | 18,443
Endocrine System 565 | 18,511
Cardiovascular System 564 | 17,957
Skin and soft tissues 563 | 18,114
Respiratory system 561 | 17,483

Target Family

Non-IDG 278 | 11,969
Enzyme 140 | 4,146
Transcription Factor 51 | 1,400
Epigenetic 32 | 242
Ion Channel 27 | 341
Kinase 27 | 634
Transporter 11 | 473
GPCR 5 | 408
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
T-cell surface protein tactile CD96 Tbio Non-IDG -2.03517 108.7 142
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
Trafficking protein particle complex subunit 9 TRAPPC9 Tbio Non-IDG -2.14008 133.3 71
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
E3 ubiquitin-protein ligase RLIM RLIM Tbio Enzyme -1.57212 36.3 141
Folate receptor alpha FOLR1 Tchem Non-IDG -2.27944 181.4 235
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.52802 34.3 167
Ribosomal biogenesis protein LAS1L LAS1L Tdark Non-IDG -0.45120 2.84 94
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167