Development Level

Tbio 135 | 11,651
Tclin 19 | 612
Tchem 17 | 1,388
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 15 | 979
abnormal behavior 7 | 298
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 7 | 278
increased total body fat amoun... 7 | 134
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
hypoactivity 6 | 132
abnormal embryo size 5 | 220
decreased bone mineral density 5 | 126
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
hyperactivity 4 | 148
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
decreased body length 3 | 101
decreased body weight 3 | 161
decreased heart weight 3 | 27
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased circulating potassiu... 3 | 29
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
male infertility 3 | 123
small kidney 3 | 16
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal male genitalia morpho... 2 | 3
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
absent startle reflex 2 | 24
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
enlarged lymph nodes 2 | 37
enlarged urinary bladder 2 | 8
hydrometra 2 | 53
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
limb grasping 2 | 41
abnormal coat- hair morphology 1 | 19
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
cataract 1 | 92
cystolithiasis 1 | 3
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
edema 1 | 59
enlarged spleen 1 | 41
enlarged uterus 1 | 11
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
polycystic kidney 1 | 15
prolonged RR interval 1 | 8
small spleen 1 | 19
small thymus 1 | 16
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Hypogonadism 173 | 173
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 166 | 18,159
Digestive Tract 159 | 17,369
Nervous System 159 | 16,725
Skin and soft tissues 158 | 17,230
Female tissues 157 | 17,400
Male tissues 156 | 17,142
Liver and Pancreas 151 | 16,750
Blood and immune system 150 | 16,909
Urinary Tract 147 | 16,678
Respiratory system 146 | 16,393
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 84 | 12,091
Enzyme 46 | 4,145
Transcription Factor 14 | 1,400
GPCR 8 | 408
Kinase 6 | 634
Transporter 5 | 473
Ion Channel 4 | 344
Nuclear Receptor 4 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Oxygen-regulated protein 1 RP1 Tbio Non-IDG 0.30 0.88 40
U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 Tbio Non-IDG -1.84397 72.4 216
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.86143 69.8 62
Gonadotropin-releasing hormone receptor GNRHR Tclin GPCR -2.63054 444.8 313
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
RNA-binding protein 28 RBM28 Tbio Non-IDG -1.90665 82.6 111
Intraflagellar transport protein 27 homolog IFT27 Tbio Enzyme -1.24496 16.5 91