Development Level

Tbio 159 | 11,445
Tchem 75 | 1,598
Tclin 57 | 613
Tdark 1 | 6,588

Collection

RFA-RM-18-021 3 | 328
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 9 | 499
increased circulating choleste... 7 | 66
abnormal behavior 6 | 298
increased total body fat amoun... 6 | 134
abnormal embryo size 5 | 220
decreased vertical activity 5 | 208
embryonic lethality prior to t... 5 | 278
hypoactivity 5 | 132
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
abnormal gait 4 | 69
abnormal testis morphology 4 | 43
decreased lymphocyte cell numb... 4 | 83
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
hyperactivity 4 | 148
increased neutrophil cell numb... 4 | 46
increased startle reflex 4 | 112
prolonged ST segment 4 | 36
small superior vagus ganglion 4 | 74
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating amylase ... 3 | 28
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
edema 3 | 59
embryonic growth retardation 3 | 106
hydrometra 3 | 53
impaired glucose tolerance 3 | 75
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating iron lev... 3 | 30
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
prolonged QT interval 3 | 38
small testis 3 | 58
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal locomotor behavior 2 | 24
abnormal vibrissa morphology 2 | 25
absent startle reflex 2 | 24
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
decreased large unstained cell... 2 | 11
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
enlarged heart 2 | 210
enlarged uterus 2 | 11
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
tremors 2 | 39
trunk curl 2 | 16
abnormal ear morphology 1 | 9
abnormal heart left ventricle ... 1 | 16
abnormal retinal vasculature m... 1 | 27
absent vibrissae 1 | 12
decreased circulating bilirubi... 1 | 19
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased neutrophil cell numb... 1 | 42
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45

Disease

Hypertensive disease 292 | 292
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 286 | 18,159
Digestive Tract 279 | 17,369
Female tissues 278 | 17,400
Male tissues 278 | 17,142
Skin and soft tissues 278 | 17,230
Urinary Tract 278 | 16,678
Liver and Pancreas 274 | 16,750
Nervous System 272 | 16,725
Blood and immune system 271 | 16,909
Respiratory system 270 | 16,393
Cardiovascular System 249 | 15,192

Target Family

Non-IDG 132 | 12,091
Enzyme 78 | 4,145
Kinase 24 | 634
Ion Channel 14 | 344
GPCR 13 | 408
Transcription Factor 13 | 1,400
Transporter 12 | 473
Nuclear Receptor 6 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-3 EDN3 Tbio Non-IDG -2.96371 794.0 219
Glutathione S-transferase theta-2 GSTT2 Tbio Enzyme -1.25193 16.8 0
Bardet-Biedl syndrome 2 protein BBS2 Tbio Non-IDG -2.84516 693.9 69
Aquaporin-1 AQP1 Tbio Non-IDG -3.08125 1107.4 374
Serine/threonine-protein kinase OSR1 OXSR1 Tbio Kinase -0.99836 9.44 355
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A Tchem Enzyme -1.53120 38.8 218
Sodium/potassium-transporting ATPase subunit gamma FXYD2 Tclin Enzyme -1.58017 39.0 64
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Paired box protein Pax-2 PAX2 Tbio Transcription Factor -2.68609 492.0 349
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265