Development Level

Tbio 184 | 11,445
Tchem 119 | 1,598
Tclin 86 | 613
Tdark 7 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 12 | 499
increased total body fat amoun... 9 | 134
abnormal behavior 8 | 298
abnormal embryo size 7 | 220
embryonic lethality prior to t... 7 | 278
enlarged heart 7 | 210
improved glucose tolerance 7 | 79
prolonged ST segment 7 | 36
decreased body weight 6 | 161
decreased vertical activity 6 | 208
hypoactivity 6 | 132
increased circulating choleste... 6 | 66
abnormal gait 5 | 69
abnormal retina morphology 5 | 71
decreased bone mineral content 5 | 151
decreased circulating triglyce... 5 | 79
decreased lean body mass 5 | 135
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
hyperactivity 5 | 148
increased bone mineral content 5 | 108
increased circulating alkaline... 5 | 122
prolonged QT interval 5 | 38
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased circulating amylase ... 4 | 28
decreased erythrocyte cell num... 4 | 62
decreased hemoglobin content 4 | 68
decreased total body fat amoun... 4 | 207
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
impaired glucose tolerance 4 | 75
increased circulating HDL chol... 4 | 80
increased circulating total pr... 4 | 28
increased lean body mass 4 | 172
increased startle reflex 4 | 112
small superior vagus ganglion 4 | 74
decreased blood urea nitrogen ... 3 | 51
decreased circulating LDL chol... 3 | 38
decreased circulating calcium ... 3 | 36
decreased circulating chloride... 3 | 30
decreased circulating insulin ... 3 | 76
decreased heart weight 3 | 27
decreased startle reflex 3 | 75
edema 3 | 59
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating LDL chol... 3 | 13
increased circulating alanine ... 3 | 13
increased circulating calcium ... 3 | 34
increased circulating creatini... 3 | 38
increased circulating iron lev... 3 | 30
increased circulating potassiu... 3 | 29
increased heart weight 3 | 62
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
tremors 3 | 39
abnormal epididymis morphology 2 | 42
abnormal femur morphology 2 | 14
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal skin morphology 2 | 50
abnormal testis morphology 2 | 43
abnormal vertebrae morphology 2 | 18
absent startle reflex 2 | 24
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart rate 2 | 18
decreased hematocrit 2 | 46
enlarged epididymis 2 | 31
hydrometra 2 | 53
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 41
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
mammalian phenotype 2 | 17
pale yolk sac 2 | 25
small testis 2 | 58
trunk curl 2 | 16
absent vibrissae 1 | 12
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25

Disease

Hypertension 396 | 396
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 387 | 18,159
Digestive Tract 380 | 17,369
Female tissues 377 | 17,400
Skin and soft tissues 377 | 17,230
Urinary Tract 374 | 16,678
Liver and Pancreas 372 | 16,750
Male tissues 372 | 17,142
Blood and immune system 364 | 16,909
Nervous System 359 | 16,725
Respiratory system 355 | 16,393
Cardiovascular System 316 | 15,192

Target Family

Non-IDG 173 | 12,091
Enzyme 116 | 4,145
Kinase 26 | 634
GPCR 22 | 408
Ion Channel 21 | 344
Transporter 21 | 473
Transcription Factor 11 | 1,400
Nuclear Receptor 6 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Histamine H3 receptor HRH3 Tclin GPCR -2.76107 570.2 318
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 Tclin Enzyme -2.97252 871.7 197