Development Level

Tbio 185 | 11,178
Tchem 63 | 1,885
Tclin 27 | 612
Tdark 5 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 12 | 499
embryonic lethality prior to o... 10 | 239
abnormal behavior 8 | 298
abnormal embryo size 8 | 220
embryonic lethality prior to t... 8 | 278
increased circulating alkaline... 7 | 122
hypoactivity 6 | 132
abnormal bone structure 5 | 187
decreased body weight 5 | 161
decreased bone mineral density 5 | 126
decreased total body fat amoun... 5 | 207
short tibia 5 | 97
cataract 4 | 92
decreased circulating choleste... 4 | 93
decreased circulating serum al... 4 | 82
enlarged lymph nodes 4 | 37
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased fasted circulating g... 3 | 65
decreased heart weight 3 | 27
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
hydrometra 3 | 53
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased circulating potassiu... 3 | 29
male infertility 3 | 123
thrombocytosis 3 | 27
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal heart morphology 2 | 162
abnormal hindbrain development 2 | 16
abnormal iris morphology 2 | 13
abnormal locomotor behavior 2 | 24
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal pancreas morphology 2 | 13
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal vertebrae morphology 2 | 18
decreased T cell number 2 | 15
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
edema 2 | 59
impaired righting response 2 | 26
increased circulating LDL chol... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating fructosa... 2 | 13
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
small seminal vesicle 2 | 10
small superior vagus ganglion 2 | 74
thin ventricular wall 2 | 24
trunk curl 2 | 16
abnormal spleen morphology 1 | 55
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
tremors 1 | 39

Disease

Hepatomegaly 280 | 280
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 277 | 18,159
Blood and immune system 275 | 16,909
Digestive Tract 275 | 17,369
Male tissues 275 | 17,142
Female tissues 274 | 17,400
Liver and Pancreas 274 | 16,750
Skin and soft tissues 273 | 17,230
Urinary Tract 270 | 16,678
Respiratory system 266 | 16,393
Nervous System 263 | 16,725
Cardiovascular System 259 | 15,192

Target Family

Non-IDG 119 | 12,091
Enzyme 103 | 4,145
Transporter 18 | 473
Kinase 17 | 634
Ion Channel 7 | 344
Nuclear Receptor 6 | 48
Transcription Factor 5 | 1,400
Epigenetic 4 | 242
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Tumor necrosis factor receptor superfamily member 1B TNFRSF1B Tchem Non-IDG -3.67481 4484.7 712
Wilms tumor protein WT1 Tbio Transcription Factor -3.48344 3138.9 571
Ras GTPase-activating protein 2 RASA2 Tdark Enzyme -0.99879 9.85 24
Cytochrome P450 1B1 CYP1B1 Tchem Non-IDG -2.93702 904.4 260
Alpha-N-acetylgalactosaminidase NAGA Tbio Enzyme -2.21917 159.3 96
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
Ammonium transporter Rh type A RHAG Tbio Non-IDG -3.03053 1073.1 38
DNA excision repair protein ERCC-6 ERCC6 Tbio Non-IDG -2.31776 361.5 163