Development Level

Tbio 201 | 11,651
Tchem 49 | 1,388
Tclin 28 | 612
Tdark 7 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 12 | 499
embryonic lethality prior to o... 10 | 239
abnormal behavior 8 | 298
abnormal embryo size 8 | 220
embryonic lethality prior to t... 8 | 278
increased circulating alkaline... 7 | 122
hypoactivity 6 | 132
abnormal bone structure 5 | 187
decreased body weight 5 | 161
decreased bone mineral density 5 | 126
decreased total body fat amoun... 5 | 207
short tibia 5 | 97
cataract 4 | 92
decreased circulating choleste... 4 | 93
decreased circulating serum al... 4 | 82
enlarged lymph nodes 4 | 37
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased fasted circulating g... 3 | 65
decreased heart weight 3 | 27
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
hydrometra 3 | 53
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased circulating potassiu... 3 | 29
male infertility 3 | 123
thrombocytosis 3 | 27
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal heart morphology 2 | 162
abnormal hindbrain development 2 | 16
abnormal iris morphology 2 | 13
abnormal locomotor behavior 2 | 24
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal pancreas morphology 2 | 13
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal vertebrae morphology 2 | 18
decreased T cell number 2 | 15
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
edema 2 | 59
impaired righting response 2 | 26
increased circulating LDL chol... 2 | 13
increased circulating bilirubi... 2 | 16
increased circulating fructosa... 2 | 13
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
small seminal vesicle 2 | 10
small superior vagus ganglion 2 | 74
thin ventricular wall 2 | 24
trunk curl 2 | 16
abnormal spleen morphology 1 | 55
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
tremors 1 | 39

Disease

Hepatomegaly 285 | 285
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 282 | 18,159
Blood and immune system 280 | 16,909
Digestive Tract 280 | 17,369
Male tissues 280 | 17,142
Female tissues 279 | 17,400
Liver and Pancreas 279 | 16,750
Skin and soft tissues 278 | 17,230
Urinary Tract 275 | 16,678
Respiratory system 271 | 16,393
Nervous System 268 | 16,725
Cardiovascular System 264 | 15,192

Target Family

Non-IDG 119 | 12,091
Enzyme 107 | 4,145
Transporter 18 | 473
Kinase 17 | 634
Ion Channel 7 | 344
Nuclear Receptor 6 | 48
Transcription Factor 6 | 1,400
Epigenetic 4 | 242
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Aldehyde dehydrogenase X, mitochondrial ALDH1B1 Tbio Enzyme -1.73034 52.5 194
T-cell surface protein tactile CD96 Tbio Non-IDG -2.05505 111.7 205
Mannosyl-oligosaccharide glucosidase MOGS Tbio Enzyme -2.28289 185.6 149
Transmembrane protein 70, mitochondrial TMEM70 Tbio Non-IDG -1.36229 24.6 93
Thrombopoietin receptor MPL Tclin Non-IDG -2.74303 582.0 186
Protein Mpv17 MPV17 Tbio Non-IDG -1.67807 47.6 134
Mitochondrial pyruvate carrier 1 MPC1 Tbio Non-IDG -1.77095 56.4 96