Development Level

Tbio 128 | 11,178
Tchem 35 | 1,885
Tclin 16 | 612
Tdark 1 | 6,569

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 7 | 239
abnormal behavior 5 | 298
embryonic lethality prior to t... 5 | 278
decreased lean body mass 4 | 135
increased circulating alkaline... 4 | 122
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
hypoactivity 3 | 132
increased bone mineral content 3 | 108
abnormal bone structure 2 | 187
abnormal gait 2 | 69
corneal opacity 2 | 32
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
male infertility 2 | 123
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
excessive tearing 1 | 2
impaired glucose tolerance 1 | 75
increased CD4-positive, CD25-p... 1 | 1
increased CD4-positive, alpha ... 1 | 4
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased aggression 1 | 4
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating phosphat... 1 | 26
increased effector memory CD4-... 1 | 1
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Hearing Loss, Partial 180 | 180
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 178 | 18,159
Digestive Tract 177 | 17,369
Female tissues 175 | 17,400
Male tissues 175 | 17,142
Skin and soft tissues 175 | 17,230
Liver and Pancreas 174 | 16,750
Blood and immune system 173 | 16,909
Urinary Tract 173 | 16,678
Nervous System 171 | 16,725
Respiratory system 169 | 16,393
Cardiovascular System 163 | 15,192

Target Family

Non-IDG 61 | 12,091
Enzyme 59 | 4,145
Transcription Factor 23 | 1,400
Kinase 12 | 634
Epigenetic 9 | 242
Transporter 7 | 473
Ion Channel 4 | 344
GPCR 2 | 408
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Collagen alpha-6(IV) chain COL4A6 Tbio Non-IDG -1.45656 27.4 119
Gap junction beta-2 protein GJB2 Tbio Non-IDG -3.17642 1514.7 242
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
Whirlin WHRN Tbio Non-IDG -1.74958 54.1 123
Alpha-N-acetylgalactosaminidase NAGA Tbio Enzyme -2.21917 159.3 96
POU domain, class 4, transcription factor 3 POU4F3 Tbio Transcription Factor -1.80543 58.9 168
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
Splicing factor 3B subunit 4 SF3B4 Tbio Non-IDG -1.44416 28.7 222
Transcription factor 12 TCF12 Tbio Transcription Factor -2.24606 159.8 253