Development Level

Tbio 313 | 10,625
Tchem 111 | 1,890
Tdark 62 | 7,003
Tclin 49 | 602

Collection

Eligible Ion Channel Proteins 3 | 117
Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 23 | 633
preweaning lethality, incomple... 11 | 260
abnormal behavior 9 | 226
embryonic lethality prior to t... 9 | 187
decreased total body fat amoun... 7 | 186
embryonic lethality prior to o... 6 | 148
hyperactivity 6 | 108
abnormal sleep behavior 5 | 63
abnormal retina morphology 4 | 100
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased circulating glucose ... 4 | 121
decreased circulating triglyce... 4 | 83
decreased fasted circulating g... 4 | 49
increased circulating alkaline... 4 | 119
increased circulating triglyce... 4 | 24
increased mean corpuscular vol... 4 | 91
male infertility 4 | 62
abnormal behavioral response t... 3 | 52
abnormal embryo size 3 | 112
abnormal lens morphology 3 | 73
decreased circulating alkaline... 3 | 41
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
decreased mean corpuscular vol... 3 | 50
decreased startle reflex 3 | 48
enlarged heart 3 | 111
increased circulating HDL chol... 3 | 63
increased fasted circulating g... 3 | 68
increased mean corpuscular hem... 3 | 93
short tibia 3 | 82
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal heart morphology 2 | 51
abnormal iris morphology 2 | 12
abnormal kidney morphology 2 | 30
abnormal retinal pigmentation 2 | 61
decreased basophil cell number 2 | 11
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating choleste... 2 | 85
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
embryonic growth retardation 2 | 28
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating choleste... 2 | 53
increased grip strength 2 | 83
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
increased or absent threshold ... 2 | 128
increased respiratory quotient 2 | 12
tremors 2 | 34
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal heart left ventricle ... 1 | 20
abnormal locomotor activation 1 | 26
abnormal lymph node morphology 1 | 3
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
decreased IgG1 level 1 | 4
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased exploration in new e... 1 | 9
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased thoracic vertebrae n... 1 | 7
decreased vertical activity 1 | 22
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26
urinary bladder obstruction 1 | 2

Disease

Endometriosis 535 | 535
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 531 | 18,473
Liver and Pancreas 531 | 18,136
Male tissues 531 | 17,969
Female tissues 530 | 18,647
Nervous System 530 | 18,561
Endocrine System 528 | 18,512
Urinary Tract 528 | 18,444
Skin and soft tissues 527 | 18,115
Cardiovascular System 526 | 17,958
Respiratory system 526 | 17,484
Blood and immune system 525 | 17,995

Target Family

Non-IDG 317 | 11,971
Enzyme 106 | 4,146
Transcription Factor 25 | 1,400
Kinase 24 | 634
Transporter 19 | 473
Nuclear Receptor 16 | 48
GPCR 12 | 406
Ion Channel 10 | 341
Epigenetic 5 | 242
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612