Development Level

Tbio 80 | 11,651
Tchem 8 | 1,388
Tclin 7 | 612

IMPC Phenotype

preweaning lethality, complete... 8 | 979
enlarged heart 5 | 210
abnormal behavior 4 | 298
increased lean body mass 4 | 172
limb grasping 4 | 41
decreased vertical activity 3 | 208
impaired righting response 3 | 26
increased or absent threshold ... 3 | 101
preweaning lethality, incomple... 3 | 499
abnormal behavioral response t... 2 | 66
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
absent pinna reflex 2 | 23
absent startle reflex 2 | 24
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased prepulse inhibition 2 | 82
enlarged uterus 2 | 11
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating sodium l... 2 | 71
increased monocyte cell number 2 | 63
increased thermal nociceptive ... 2 | 9
increased total body fat amoun... 2 | 134
male infertility 2 | 123
prolonged PR interval 2 | 15
small superior vagus ganglion 2 | 74
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal ear morphology 1 | 9
abnormal locomotor activation 1 | 16
abnormal nail morphology 1 | 8
abnormal pupil morphology 1 | 2
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased cellular hemoglobin ... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
macrophthalmia 1 | 2
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
small testis 1 | 58
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Electroretinogram abnormal 95 | 95
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 93 | 18,159
Digestive Tract 90 | 17,369
Nervous System 90 | 16,725
Skin and soft tissues 89 | 17,230
Blood and immune system 87 | 16,909
Female tissues 86 | 17,400
Male tissues 86 | 17,142
Liver and Pancreas 84 | 16,750
Urinary Tract 84 | 16,678
Respiratory system 81 | 16,393
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 27 | 4,145
Ion Channel 8 | 344
Transcription Factor 6 | 1,400
Kinase 4 | 634
GPCR 2 | 408
Nuclear Receptor 1 | 48
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Oxygen-regulated protein 1 RP1 Tbio Non-IDG 0.30 0.88 40
U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 Tbio Non-IDG -1.84397 72.4 216
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.86143 69.8 62
Intraflagellar transport protein 27 homolog IFT27 Tbio Enzyme -1.24496 16.5 91
Visual system homeobox 1 VSX1 Tbio Transcription Factor -1.70315 49.6 119
Neurogenic locus notch homolog protein 3 NOTCH3 Tchem Non-IDG -2.67185 458.4 499
U4/U6 small nuclear ribonucleoprotein Prp3 PRPF3 Tbio Non-IDG -1.73686 54.3 123
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.05503 10.4 159