Development Level

Tbio 138 | 11,445
Tchem 30 | 1,598
Tclin 22 | 613
Tdark 2 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 9 | 278
decreased bone mineral content 7 | 151
decreased mean corpuscular vol... 7 | 79
abnormal behavior 6 | 298
male infertility 6 | 123
abnormal bone structure 5 | 187
decreased circulating choleste... 5 | 93
increased total body fat amoun... 5 | 134
abnormal embryo size 4 | 220
decreased bone mineral density 4 | 126
decreased erythrocyte cell num... 4 | 62
decreased hemoglobin content 4 | 68
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
increased lean body mass 4 | 172
short tibia 4 | 97
decreased body length 3 | 101
decreased circulating HDL chol... 3 | 68
decreased circulating glucose ... 3 | 126
decreased circulating potassiu... 3 | 20
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular hem... 3 | 31
decreased neutrophil cell numb... 3 | 42
decreased red blood cell distr... 3 | 41
enlarged heart 3 | 210
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
preweaning lethality, incomple... 3 | 499
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased basophil cell number 2 | 16
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased body length 2 | 32
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased erythrocyte cell num... 2 | 39
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
thin ventricular wall 2 | 24
thrombocytosis 2 | 27
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal sleep behavior 1 | 70
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating creatine... 1 | 4
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
enlarged urinary bladder 1 | 8
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74

Disease

Dysarthria 192 | 192
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 190 | 18,159
Digestive Tract 189 | 17,369
Nervous System 189 | 16,725
Female tissues 188 | 17,400
Liver and Pancreas 187 | 16,750
Male tissues 187 | 17,142
Skin and soft tissues 187 | 17,230
Urinary Tract 186 | 16,678
Blood and immune system 184 | 16,909
Respiratory system 184 | 16,393
Cardiovascular System 180 | 15,192

Target Family

Non-IDG 87 | 12,091
Enzyme 68 | 4,145
Transporter 11 | 473
Ion Channel 8 | 344
Kinase 7 | 634
Epigenetic 5 | 242
Transcription Factor 3 | 1,400
Nuclear Receptor 2 | 48
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Rotatin RTTN Tbio Non-IDG -0.87856 9.51 13
Tetratricopeptide repeat protein 19, mitochondrial TTC19 Tbio Non-IDG -0.95371 10.6 38
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 Tclin Enzyme -2.97252 871.7 197
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.37513 23.0 104
Vacuolar protein sorting-associated protein 13A VPS13A Tbio Non-IDG -2.19966 172.3 22
DNA-directed RNA polymerase III subunit RPC2 POLR3B Tbio Enzyme -1.25377 19.0 105
Anoctamin-10 ANO10 Tbio Non-IDG -1.22069 14.6 54
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120