Development Level

Tbio 469 | 11,651
Tchem 61 | 1,388
Tdark 51 | 6,593
Tclin 20 | 612

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, incomple... 22 | 499
preweaning lethality, complete... 19 | 979
abnormal behavior 13 | 298
decreased total body fat amoun... 9 | 207
embryonic lethality prior to t... 9 | 278
abnormal bone structure 7 | 187
abnormal sleep behavior 7 | 70
cataract 7 | 92
increased bone mineral density 7 | 72
abnormal coat-hair pigmentatio... 6 | 64
decreased body weight 6 | 161
decreased circulating glucose ... 6 | 126
decreased lean body mass 6 | 135
decreased vertical activity 6 | 208
enlarged heart 6 | 210
increased lean body mass 6 | 172
short tibia 6 | 97
abnormal embryo size 5 | 220
abnormal lens morphology 5 | 81
decreased bone mineral content 5 | 151
hyperactivity 5 | 148
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased fasted circulating g... 5 | 76
increased mean corpuscular hem... 5 | 36
increased startle reflex 5 | 112
abnormal behavioral response t... 4 | 66
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
decreased circulating choleste... 4 | 93
decreased circulating insulin ... 4 | 76
decreased grip strength 4 | 116
decreased prepulse inhibition 4 | 82
increased mean corpuscular hem... 4 | 96
abnormal eye morphology 3 | 68
abnormal humerus morphology 3 | 11
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating alanine ... 3 | 47
decreased circulating serum al... 3 | 82
decreased mean corpuscular hem... 3 | 31
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
increased circulating choleste... 3 | 66
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
increased vertical activity 3 | 24
prenatal lethality prior to he... 3 | 87
abnormal femur morphology 2 | 14
abnormal hair growth 2 | 10
abnormal lung morphology 2 | 26
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
absent vibrissae 2 | 12
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating phosphat... 2 | 27
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
edema 2 | 59
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased body length 2 | 32
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating sodium l... 2 | 71
increased red blood cell distr... 2 | 34
pale yolk sac 2 | 25
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal tail movements 1 | 12
convulsive seizures 1 | 13
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased food intake 1 | 13
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
increased mean corpuscular vol... 1 | 92
long tibia 1 | 25
vertebral fusion 1 | 23

Disease

Duchenne muscular dystrophy 601 | 601
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 592 | 18,159
Digestive Tract 591 | 17,369
Skin and soft tissues 591 | 17,230
Male tissues 590 | 17,142
Blood and immune system 586 | 16,909
Female tissues 585 | 17,400
Liver and Pancreas 585 | 16,750
Nervous System 584 | 16,725
Urinary Tract 581 | 16,678
Cardiovascular System 580 | 15,192
Respiratory system 578 | 16,393

Target Family

Non-IDG 409 | 12,091
Enzyme 119 | 4,145
Transcription Factor 20 | 1,400
Kinase 17 | 634
Transporter 17 | 473
GPCR 7 | 408
Ion Channel 7 | 344
Nuclear Receptor 3 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Protein TANC1 TANC1 Tdark Non-IDG -1.18264 15.5 31
Protein zyg-11 homolog B ZYG11B Tdark Non-IDG -0.49136 2.50 52
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Glycerol kinase 3 GK3P Tdark Kinase -1.84692 109.0 0