Development Level

Tbio 117 | 11,651
Tchem 24 | 1,388
Tclin 14 | 612
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, complete... 23 | 979
abnormal behavior 7 | 298
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 6 | 499
decreased total body fat amoun... 5 | 207
decreased body weight 4 | 161
decreased lean body mass 4 | 135
hyperactivity 4 | 148
increased lean body mass 4 | 172
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating aspartat... 3 | 34
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased heart rate 3 | 18
decreased vertical activity 3 | 208
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
impaired glucose tolerance 3 | 75
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
abnormal kidney morphology 2 | 65
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased heart weight 2 | 27
decreased mean corpuscular vol... 2 | 79
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased or absent threshold ... 2 | 101
increased prepulse inhibition 2 | 32
increased startle reflex 2 | 112
prenatal lethality 2 | 28
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
absent adrenal gland 1 | 2
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased coping response 1 | 4
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
limb grasping 1 | 41
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prolonged RR interval 1 | 8
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Downward slant of palpebral fissure 158 | 158
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 155 | 18,159
Digestive Tract 153 | 17,369
Male tissues 153 | 17,142
Nervous System 153 | 16,725
Skin and soft tissues 153 | 17,230
Blood and immune system 152 | 16,909
Female tissues 151 | 17,400
Liver and Pancreas 150 | 16,750
Respiratory system 150 | 16,393
Urinary Tract 149 | 16,678
Cardiovascular System 146 | 15,192

Target Family

Non-IDG 78 | 12,091
Enzyme 39 | 4,145
Kinase 17 | 634
Transcription Factor 14 | 1,400
Epigenetic 8 | 242
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
AMME syndrome candidate gene 1 protein AMMECR1 Tbio Non-IDG -0.63077 4.76 84
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
F-box/LRR-repeat protein 4 FBXL4 Tbio Non-IDG -1.13805 13.4 82
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 Tbio Enzyme -1.43805 32.2 112
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.46402 298.9 76