Development Level

Tbio 365 | 11,651
Tchem 72 | 1,388
Tdark 43 | 6,593
Tclin 19 | 612

Collection

Kinase: IDG Consortium (Target... 7 | 125
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 30 | 499
preweaning lethality, complete... 24 | 979
decreased total body fat amoun... 15 | 207
decreased body weight 14 | 161
abnormal behavior 11 | 298
decreased bone mineral content 10 | 151
embryonic lethality prior to t... 10 | 278
hypoactivity 10 | 132
increased total body fat amoun... 10 | 134
decreased body length 9 | 101
decreased lean body mass 9 | 135
increased bone mineral content 8 | 108
abnormal bone structure 7 | 187
abnormal embryo size 7 | 220
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
increased lean body mass 7 | 172
abnormal sleep behavior 6 | 70
decreased circulating glucose ... 6 | 126
decreased circulating serum al... 6 | 82
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
abnormal cranium morphology 5 | 36
decreased caudal vertebrae num... 5 | 53
decreased circulating alanine ... 5 | 47
decreased mean corpuscular vol... 5 | 79
hyperactivity 5 | 148
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
male infertility 5 | 123
abnormal cornea morphology 4 | 31
abnormal retina morphology 4 | 71
abnormal tooth morphology 4 | 24
cataract 4 | 92
decreased circulating total pr... 4 | 49
decreased circulating triglyce... 4 | 79
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
increased circulating triglyce... 4 | 42
increased mean corpuscular hem... 4 | 36
increased startle reflex 4 | 112
limb grasping 4 | 41
persistence of hyaloid vascula... 4 | 33
prolonged QT interval 4 | 38
thrombocytopenia 4 | 56
abnormal coat appearance 3 | 31
abnormal coat-hair pigmentatio... 3 | 64
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
corneal opacity 3 | 32
decreased circulating LDL chol... 3 | 38
decreased circulating insulin ... 3 | 76
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 50
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
female infertility 3 | 60
impaired glucose tolerance 3 | 75
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating calcium ... 3 | 34
increased circulating potassiu... 3 | 29
increased circulating sodium l... 3 | 71
increased hematocrit 3 | 46
increased or absent threshold ... 3 | 101
increased red blood cell distr... 3 | 34
increased vertical activity 3 | 24
prolonged ST segment 3 | 36
tremors 3 | 39
abnormal behavioral response t... 2 | 66
decreased IgG1 level 2 | 8
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased food intake 2 | 13
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased circulating amylase ... 2 | 25
increased circulating chloride... 2 | 41
increased circulating magnesiu... 2 | 10
increased circulating phosphat... 2 | 26
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small testis 2 | 58
thin ventricular wall 2 | 24
thrombocytosis 2 | 27

Disease

Down syndrome 499 | 499
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 488 | 18,159
Nervous System 487 | 16,725
Digestive Tract 485 | 17,369
Male tissues 484 | 17,142
Skin and soft tissues 483 | 17,230
Female tissues 482 | 17,400
Liver and Pancreas 482 | 16,750
Urinary Tract 478 | 16,678
Blood and immune system 475 | 16,909
Respiratory system 473 | 16,393
Cardiovascular System 460 | 15,192

Target Family

Non-IDG 309 | 12,091
Enzyme 89 | 4,145
Transcription Factor 34 | 1,400
Kinase 29 | 634
Transporter 14 | 473
Epigenetic 9 | 242
GPCR 9 | 408
Ion Channel 6 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275