Development Level

Tbio 367 | 10,625
Tchem 103 | 1,890
Tdark 58 | 7,003
Tclin 20 | 602

Collection

Eligible Kinase Proteins 7 | 134
Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, incomple... 19 | 260
preweaning lethality, complete... 17 | 633
decreased body weight 14 | 174
decreased total body fat amoun... 14 | 186
decreased lean body mass 12 | 195
abnormal behavior 11 | 226
decreased bone mineral content 11 | 157
decreased grip strength 10 | 123
abnormal retina morphology 9 | 100
decreased body length 9 | 108
abnormal sleep behavior 8 | 63
embryonic lethality prior to t... 8 | 187
abnormal bone structure 7 | 131
decreased bone mineral density 7 | 126
decreased circulating serum al... 7 | 79
increased circulating alkaline... 7 | 119
increased lean body mass 7 | 107
abnormal retinal pigmentation 6 | 61
decreased circulating HDL chol... 6 | 77
decreased circulating alanine ... 6 | 53
decreased circulating insulin ... 6 | 75
hypoactivity 6 | 89
increased bone mineral content 6 | 92
male infertility 6 | 62
abnormal embryo size 5 | 112
abnormal lens morphology 5 | 73
abnormal tooth morphology 5 | 24
decreased Ly6C low monocyte nu... 5 | 23
decreased circulating choleste... 5 | 85
decreased circulating triglyce... 5 | 83
decreased rib number 5 | 59
hyperactivity 5 | 108
persistence of hyaloid vascula... 5 | 22
abnormal cornea morphology 4 | 24
abnormal cranium morphology 4 | 32
decreased NK T cell number 4 | 28
decreased circulating glucose ... 4 | 121
decreased circulating total pr... 4 | 41
decreased prepulse inhibition 4 | 52
impaired glucose tolerance 4 | 52
increased circulating sodium l... 4 | 71
increased exploration in new e... 4 | 56
increased or absent threshold ... 4 | 128
increased startle reflex 4 | 38
increased total body fat amoun... 4 | 57
limb grasping 4 | 35
thrombocytopenia 4 | 46
abnormal coat/hair pigmentatio... 3 | 54
abnormal retinal blood vessel ... 3 | 18
abnormal snout morphology 3 | 18
cataract 3 | 26
corneal opacity 3 | 25
decreased circulating LDL chol... 3 | 37
decreased circulating alkaline... 3 | 41
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 19
decreased mean corpuscular vol... 3 | 50
decreased mean platelet volume 3 | 12
decreased monocyte cell number 3 | 28
embryonic lethality prior to o... 3 | 148
enlarged heart 3 | 111
female infertility 3 | 34
immune system phenotype 3 | 17
improved glucose tolerance 3 | 56
increased blood urea nitrogen ... 3 | 44
increased circulating magnesiu... 3 | 10
increased circulating phosphat... 3 | 24
increased fasted circulating g... 3 | 68
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal kidney morphology 2 | 30
abnormal neural tube closure 2 | 37
decreased circulating iron lev... 2 | 25
decreased circulating phosphat... 2 | 15
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
increased body weight 2 | 42
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating potassiu... 2 | 31
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased mean corpuscular hem... 2 | 25
increased mean platelet volume 2 | 19
oligodactyly 2 | 14
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82

Disease

Down syndrome 548 | 548
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 542 | 18,561
Female tissues 541 | 18,647
Digestive Tract 540 | 18,473
Urinary Tract 540 | 18,444
Endocrine System 539 | 18,512
Cardiovascular System 538 | 17,958
Liver and Pancreas 538 | 18,136
Male tissues 537 | 17,969
Blood and immune system 536 | 17,995
Skin and soft tissues 536 | 18,115
Respiratory system 531 | 17,484

Target Family

Non-IDG 337 | 11,969
Enzyme 99 | 4,146
Transcription Factor 37 | 1,400
Kinase 31 | 634
Transporter 14 | 473
GPCR 10 | 408
Ion Channel 10 | 341
Epigenetic 9 | 242
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Tchem Kinase -1.76072 56.9 0
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.46304 29.4 8
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
Protein C-ets-2 ETS2 Tbio Transcription Factor -2.39443 244.9 192
Protein dopey-2 DOPEY2 Tbio Non-IDG -0.67912 6.04 14
Dystrobrevin alpha DTNA Tbio Non-IDG -2.24566 173.6 138
Dual specificity tyrosine-phosphorylation-regulated kinase 1B DYRK1B Tchem Kinase -1.60085 49.5 239
C2 domain-containing protein 2 C2CD2 Tdark Non-IDG 0.30 0.67 46
Protein prune homolog 2 PRUNE2 Tbio Non-IDG -1.01904 11.2 76
Protein kinase C beta type PRKCB Tchem Kinase -1.97915 83.5 530