Development Level

Tbio 89 | 10,625
Tclin 32 | 602
Tchem 31 | 1,890
Tdark 3 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
abnormal kidney morphology 3 | 30
abnormal seminal vesicle morph... 3 | 47
decreased body weight 3 | 174
decreased circulating alanine ... 3 | 53
decreased total body fat amoun... 3 | 186
increased blood urea nitrogen ... 3 | 44
abnormal behavior 2 | 226
abnormal epididymis morphology 2 | 31
abnormal retinal pigmentation 2 | 61
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased leukocyte cell numbe... 2 | 54
enlarged heart 2 | 111
hyperactivity 2 | 108
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased startle reflex 2 | 38
preweaning lethality, incomple... 2 | 260
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal eye morphology 1 | 38
abnormal forced expiratory flo... 1 | 1
abnormal forebrain development 1 | 18
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal sacral vertebrae morp... 1 | 5
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal whole-body plethysmog... 1 | 4
absent heartbeat 1 | 6
altered righting response 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased bone mineral content 1 | 157
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased food intake 1 | 6
decreased grip strength 1 | 123
decreased lymphocyte cell numb... 1 | 9
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased tidal volume 1 | 1
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged liver 1 | 3
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lymphocyte cell numb... 1 | 9
increased monocyte cell number 1 | 27
increased neutrophil cell numb... 1 | 15
male infertility 1 | 62
polydactyly 1 | 22
tremors 1 | 34

Disease

Diarrhea 155 | 155
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 153 | 18,472
Female tissues 153 | 18,646
Urinary Tract 153 | 18,443
Endocrine System 152 | 18,511
Nervous System 152 | 18,560
Skin and soft tissues 152 | 18,114
Liver and Pancreas 150 | 18,135
Blood and immune system 147 | 17,994
Male tissues 146 | 17,968
Cardiovascular System 145 | 17,957
Respiratory system 143 | 17,483

Target Family

Non-IDG 76 | 11,969
Enzyme 45 | 4,146
Transporter 12 | 473
Kinase 10 | 634
GPCR 4 | 408
Ion Channel 4 | 341
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
CD40 ligand CD40LG Tchem Non-IDG -4.56976 36580.5 1095
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.60310 374.7 140
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809
Maltase-glucoamylase, intestinal MGAM Tclin Enzyme -4.50018 27956.4 30
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Carboxypeptidase E CPE Tbio Enzyme -2.99888 983.1 216
Sucrase-isomaltase, intestinal SI Tchem Enzyme -1.83971 67.3 52
Enteropeptidase TMPRSS15 Tchem Enzyme -2.77649 569.6 104
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312