Development Level

Tbio 151 | 11,445
Tclin 50 | 613
Tchem 48 | 1,598
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
decreased body weight 5 | 161
decreased total body fat amoun... 5 | 207
increased blood urea nitrogen ... 5 | 48
abnormal behavior 4 | 298
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased circulating insulin ... 4 | 76
enlarged heart 4 | 210
hypoactivity 4 | 132
increased lymphocyte cell numb... 4 | 32
preweaning lethality, incomple... 4 | 499
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
abnormal kidney morphology 3 | 65
abnormal lung morphology 3 | 26
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased mean corpuscular vol... 3 | 79
enlarged lymph nodes 3 | 37
impaired glucose tolerance 3 | 75
impaired righting response 3 | 26
improved glucose tolerance 3 | 79
increased circulating alkaline... 3 | 122
increased circulating amylase ... 3 | 25
increased circulating total pr... 3 | 28
increased grip strength 3 | 41
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular hem... 3 | 96
increased neutrophil cell numb... 3 | 46
increased startle reflex 3 | 112
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased eosinophil cell numb... 2 | 11
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
short tibia 2 | 97
small seminal vesicle 2 | 10
small testis 2 | 58
abnormal embryo turning 1 | 31
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased aggression 1 | 4
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Diarrhea 253 | 253
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 242 | 17,369
Endocrine System 242 | 18,159
Blood and immune system 239 | 16,909
Female tissues 238 | 17,400
Skin and soft tissues 238 | 17,230
Liver and Pancreas 233 | 16,750
Male tissues 230 | 17,142
Urinary Tract 230 | 16,678
Nervous System 220 | 16,725
Respiratory system 220 | 16,393
Cardiovascular System 192 | 15,192

Target Family

Non-IDG 107 | 12,091
Enzyme 78 | 4,145
Transporter 20 | 473
Kinase 17 | 634
Ion Channel 12 | 344
Transcription Factor 8 | 1,400
GPCR 6 | 408
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.37125 226.3 178
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 PDZD3 Tbio Non-IDG -0.76581 6.17 121
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Malonyl-CoA decarboxylase, mitochondrial MLYCD Tchem Enzyme -1.70434 46.1 67