Development Level

Tbio 90 | 10,625
Tchem 41 | 1,890
Tclin 17 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 9 | 633
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
increased circulating alkaline... 4 | 119
preweaning lethality, incomple... 4 | 260
abnormal lens morphology 3 | 73
decreased total body fat amoun... 3 | 186
increased circulating aspartat... 3 | 17
increased mean corpuscular hem... 3 | 93
abnormal gait 2 | 51
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating amylase ... 2 | 24
decreased circulating fructosa... 2 | 31
decreased circulating insulin ... 2 | 75
decreased circulating phosphat... 2 | 15
decreased circulating triglyce... 2 | 83
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased circulating choleste... 2 | 53
increased circulating total pr... 2 | 20
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased respiratory quotient 2 | 12
persistence of hyaloid vascula... 2 | 22
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 12
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities/... 1 | 3
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
cataract 1 | 26
decreased CD4-positive, CD25-p... 1 | 24
decreased CD5-positive Ly6C-po... 1 | 4
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased spleen weight 1 | 13
impaired righting response 1 | 19
increased B cell number 1 | 23
increased CD4-positive NK T ce... 1 | 3
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased NK T cell number 1 | 11
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating calcium ... 1 | 32
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased gamma-delta T cell n... 1 | 16
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased memory-marker CD4-po... 1 | 3
increased rib number 1 | 41
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
lethargy 1 | 5
narrow eye opening 1 | 15
small seminal vesicle 1 | 6
small testis 1 | 37
stereotypic behavior 1 | 3
straub tail 1 | 26
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34
trunk curl 1 | 15

Disease

Diabetes Mellitus, Non-Insulin-Dependent 157 | 157
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 156 | 18,473
Liver and Pancreas 156 | 18,136
Female tissues 155 | 18,647
Nervous System 155 | 18,561
Endocrine System 154 | 18,512
Male tissues 153 | 17,969
Blood and immune system 152 | 17,995
Cardiovascular System 152 | 17,958
Skin and soft tissues 152 | 18,115
Urinary Tract 151 | 18,444
Respiratory system 147 | 17,484

Target Family

Non-IDG 68 | 11,971
Enzyme 40 | 4,146
Transcription Factor 20 | 1,400
Transporter 9 | 473
Kinase 7 | 634
Ion Channel 5 | 341
GPCR 4 | 406
Nuclear Receptor 3 | 48
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Hemopexin HPX Tbio Non-IDG -2.83364 677.6 363