Development Level

Tbio 102 | 11,445
Tchem 47 | 1,598
Tclin 25 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased total body fat amoun... 6 | 207
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
abnormal embryo size 4 | 220
decreased circulating serum al... 4 | 82
decreased hemoglobin content 4 | 68
decreased mean corpuscular vol... 4 | 79
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
enlarged heart 4 | 210
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 76
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating alkaline... 3 | 46
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
hypoactivity 3 | 132
improved glucose tolerance 3 | 79
increased circulating chloride... 3 | 41
increased heart weight 3 | 62
increased lean body mass 3 | 172
increased startle reflex 3 | 112
prenatal lethality prior to he... 3 | 87
prolonged ST segment 3 | 36
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
decreased basophil cell number 2 | 16
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
edema 2 | 59
hyperactivity 2 | 148
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
increased total body fat amoun... 2 | 134
male infertility 2 | 123
pallor 2 | 34
prolonged QT interval 2 | 38
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased total retina thickne... 1 | 17
increased aggression 1 | 4
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Dementia 175 | 175
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 170 | 18,159
Digestive Tract 169 | 17,369
Female tissues 168 | 17,400
Blood and immune system 166 | 16,909
Nervous System 166 | 16,725
Skin and soft tissues 166 | 17,230
Liver and Pancreas 165 | 16,750
Urinary Tract 165 | 16,678
Male tissues 163 | 17,142
Respiratory system 160 | 16,393
Cardiovascular System 156 | 15,192

Target Family

Non-IDG 86 | 12,091
Enzyme 51 | 4,145
Transporter 14 | 473
GPCR 6 | 408
Transcription Factor 6 | 1,400
Ion Channel 4 | 344
Kinase 4 | 634
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
RNA binding protein fox-1 homolog 3 RBFOX3 Tbio Non-IDG -3.23341 1462.9 208
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
Ceroid-lipofuscinosis neuronal protein 6 CLN6 Tbio Non-IDG -1.87357 0.00000 103
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
PHD finger protein 1 PHF1 Tbio Epigenetic -2.14039 127.5 199
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252