Development Level

Tbio 96 | 11,445
Tchem 20 | 1,598
Tclin 15 | 613
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 20 | 979
abnormal behavior 8 | 298
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 5 | 278
decreased bone mineral content 4 | 151
decreased grip strength 4 | 116
decreased total body fat amoun... 4 | 207
hyperactivity 4 | 148
increased bone mineral content 4 | 108
abnormal gait 3 | 69
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
hypoactivity 3 | 132
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
corneal opacity 2 | 32
decreased basophil cell number 2 | 16
decreased body weight 2 | 161
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
decreased vertical activity 2 | 208
enlarged lymph nodes 2 | 37
increased body length 2 | 32
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal hair growth 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
brachydactyly 1 | 19
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased lactate dehydrogenas... 1 | 16
decreased lumbar vertebrae num... 1 | 2
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
enlarged urinary bladder 1 | 8
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased vertical activity 1 | 24
limb grasping 1 | 41
male infertility 1 | 123
polycystic kidney 1 | 15
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
prolonged RR interval 1 | 8
respiratory system phenotype 1 | 2
small adrenal glands 1 | 16
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Deglutition Disorders 132 | 132
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 129 | 17,369
Endocrine System 129 | 18,159
Skin and soft tissues 129 | 17,230
Male tissues 128 | 17,142
Female tissues 127 | 17,400
Liver and Pancreas 126 | 16,750
Nervous System 126 | 16,725
Blood and immune system 124 | 16,909
Urinary Tract 124 | 16,678
Cardiovascular System 120 | 15,192
Respiratory system 119 | 16,393

Target Family

Non-IDG 63 | 12,091
Enzyme 38 | 4,145
Ion Channel 11 | 344
Kinase 8 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
tRNA-splicing endonuclease subunit Sen34 TSEN34 Tdark Enzyme -0.75841 5.30 26
AFG3-like protein 2 AFG3L2 Tbio Enzyme -1.58716 39.9 164
Vacuolar protein sorting-associated protein 13A VPS13A Tbio Non-IDG -2.19966 172.3 22
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.73791 419.9 129