Development Level

Tbio 58 | 10,625
Tchem 18 | 1,890
Tclin 11 | 602
Tdark 10 | 7,003

Collection

GPCR: IDG Consortium (Complete/Control) 1 | 26
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

abnormal bone structure 3 | 131
increased circulating HDL chol... 3 | 63
increased mean corpuscular hem... 3 | 93
increased neutrophil cell numb... 3 | 15
preweaning lethality, complete... 3 | 633
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
decreased CD4-positive, CD25-p... 2 | 24
decreased body length 2 | 108
decreased body weight 2 | 174
decreased circulating HDL chol... 2 | 77
decreased effector memory CD8-... 2 | 24
decreased gamma-delta T cell n... 2 | 18
decreased neutrophil cell numb... 2 | 37
enlarged heart 2 | 111
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased circulating serum al... 2 | 25
increased eosinophil cell numb... 2 | 9
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
abnormal behavior 1 | 226
abnormal coat-hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal kidney morphology 1 | 30
abnormal lymph node morphology 1 | 3
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased KLRG1+ CD4 alpha bet... 1 | 5
increased KLRG1+ CD8 alpha bet... 1 | 2
increased KLRG1-positive CD4-n... 1 | 1
increased KLRG1-positive CD4-p... 1 | 3
increased KLRG1-positive NK ce... 1 | 9
increased KLRG1-positive T-hel... 1 | 2
increased KLRG1-positive gamma... 1 | 2
increased Ly6C low monocyte nu... 1 | 8
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased effector memory T-he... 1 | 5
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lymphocyte cell numb... 1 | 9
increased memory CD4-positive,... 1 | 3
increased memory-marker CD4-ne... 1 | 1
increased monocyte cell number 1 | 27
increased myeloid cell number 1 | 2
increased total body fat amoun... 1 | 57
male infertility 1 | 62
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

Crohn Disease 97 | 97
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 96 | 17,994
Digestive Tract 96 | 18,472
Female tissues 96 | 18,646
Nervous System 96 | 18,560
Urinary Tract 96 | 18,443
Liver and Pancreas 95 | 18,135
Cardiovascular System 94 | 17,957
Endocrine System 94 | 18,511
Male tissues 93 | 17,968
Respiratory system 93 | 17,483
Skin and soft tissues 93 | 18,114

Target Family

Non-IDG 57 | 11,969
Enzyme 18 | 4,146
Transcription Factor 8 | 1,400
GPCR 3 | 408
Nuclear Receptor 3 | 48
Epigenetic 2 | 242
Kinase 2 | 634
Transporter 2 | 473
Ion Channel 1 | 341
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Endoplasmic reticulum aminopeptidase 2 ERAP2 Tchem Enzyme -1.68056 46.0 70
Transcription regulator protein BACH2 BACH2 Tbio Transcription Factor -1.84608 77.3 159
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539
R-spondin-3 RSPO3 Tbio Non-IDG -1.18455 17.3 94
Transmembrane protein 258 TMEM258 Tdark Non-IDG -0.24304 1.54 5
F-BAR and double SH3 domains protein 2 FCHSD2 Tbio Non-IDG -1.52274 34.3 58
Zinc finger MIZ domain-containing protein 1 ZMIZ1 Tbio Transcription Factor -1.55439 34.5 113
Putative homeodomain transcription factor 1 PHTF1 Tdark Non-IDG -1.09131 12.0 24