Development Level

Tbio 125 | 11,445
Tchem 16 | 1,598
Tclin 9 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 20 | 979
abnormal embryo size 7 | 220
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
embryonic growth retardation 5 | 106
increased total body fat amoun... 5 | 134
increased circulating alkaline... 4 | 122
small superior vagus ganglion 4 | 74
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal tail morphology 3 | 25
decreased bone mineral content 3 | 151
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
enlarged heart 3 | 210
increased bone mineral density 3 | 72
small testis 3 | 58
abnormal bone mineralization 2 | 38
abnormal facial morphology 2 | 17
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal vertebrae morphology 2 | 18
cataract 2 | 92
cleft palate 2 | 8
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
irregularly shaped pupil 2 | 7
long tibia 2 | 25
mammalian phenotype 2 | 17
pallor 2 | 34
tremors 2 | 39
abnormal allantois morphology 1 | 8
abnormal body wall morphology 1 | 9
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal left-right axis patte... 1 | 2
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating phosphat... 1 | 27
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged heart atrium 1 | 4
enlarged stomach 1 | 2
hemorrhage 1 | 23
impaired righting response 1 | 26
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
microphthalmia 1 | 26
premature death 1 | 5
prenatal lethality 1 | 28
small thymus 1 | 16
thin ventricular wall 1 | 24
unresponsive to tactile stimul... 1 | 8

Disease

Craniofacial Abnormalities 151 | 151
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 147 | 18,159
Male tissues 144 | 17,142
Digestive Tract 143 | 17,369
Female tissues 141 | 17,400
Skin and soft tissues 141 | 17,230
Nervous System 139 | 16,725
Urinary Tract 139 | 16,678
Blood and immune system 136 | 16,909
Liver and Pancreas 136 | 16,750
Respiratory system 132 | 16,393
Cardiovascular System 125 | 15,192

Target Family

Non-IDG 60 | 12,091
Transcription Factor 49 | 1,400
Enzyme 20 | 4,145
Kinase 10 | 634
Epigenetic 5 | 242
GPCR 3 | 408
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
Folate receptor alpha FOLR1 Tchem Non-IDG -2.33242 206.1 303
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Treacle protein TCOF1 Tbio Non-IDG -3.44117 2743.5 131
Zinc finger transcription factor Trps1 TRPS1 Tbio Transcription Factor -1.98756 107.0 69
Retinal homeobox protein Rx RAX Tbio Transcription Factor -0.52554 4.68 205