Development Level

Tbio 35 | 10,625
Tchem 12 | 1,890
Tclin 6 | 602
Tdark 6 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
embryonic lethality prior to t... 3 | 187
increased hemoglobin content 2 | 45
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal coat-hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal response to tactile s... 1 | 16
abnormal seminal vesicle morph... 1 | 47
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
absent vibrissae 1 | 14
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating triglyce... 1 | 24
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
long tibia 1 | 13
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small kidney 1 | 10

Disease

Coronary heart disease 59 | 59
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 58 | 17,994
Digestive Tract 58 | 18,472
Endocrine System 58 | 18,511
Female tissues 58 | 18,646
Liver and Pancreas 58 | 18,135
Male tissues 58 | 17,968
Nervous System 58 | 18,560
Urinary Tract 58 | 18,443
Cardiovascular System 57 | 17,957
Respiratory system 57 | 17,483
Skin and soft tissues 57 | 18,114

Target Family

Non-IDG 27 | 11,969
Enzyme 19 | 4,146
Transcription Factor 4 | 1,400
Transporter 3 | 473
GPCR 2 | 408
Kinase 2 | 634
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.36387 2061.0 806
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Transcription factor 21 TCF21 Tbio Transcription Factor -1.77727 57.8 121
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.85328 651.4 0
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.75360 59.1 34
Proline/serine-rich coiled-coil protein 1 PSRC1 Tbio Non-IDG -1.31390 21.6 121
HHIP-like protein 1 HHIPL1 Tdark Non-IDG 0.35 0.44 19
Macoilin TMEM57 Tbio Non-IDG -0.59364 4.61 49
Platelet-activating factor acetylhydrolase PLA2G7 Tchem Enzyme -2.34913 300.0 189
Angiotensin-converting enzyme ACE Tclin Enzyme -4.51343 29360.4 544