Development Level

Tbio 160 | 11,651
Tchem 63 | 1,388
Tclin 41 | 612
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 7 | 499
abnormal seminal vesicle morph... 6 | 114
decreased vertical activity 6 | 208
enlarged heart 6 | 210
abnormal lens morphology 5 | 81
decreased circulating triglyce... 5 | 79
embryonic lethality prior to o... 5 | 239
abnormal embryo size 4 | 220
decreased bone mineral content 4 | 151
increased circulating alkaline... 4 | 122
increased lymphocyte cell numb... 4 | 32
prolonged ST segment 4 | 36
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased lymphocyte cell numb... 3 | 83
increased circulating choleste... 3 | 66
increased circulating triglyce... 3 | 42
increased leukocyte cell numbe... 3 | 47
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal snout morphology 2 | 23
abnormal vibrissa morphology 2 | 25
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased heart rate 2 | 18
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
enlarged uterus 2 | 11
increased circulating bilirubi... 2 | 16
increased circulating iron lev... 2 | 30
increased grip strength 2 | 41
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
short tibia 2 | 97
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal posture 1 | 2
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 12
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small kidney 1 | 16
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
trunk curl 1 | 16

Disease

Coronary artery disease 268 | 268
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 262 | 18,159
Digestive Tract 261 | 17,369
Liver and Pancreas 257 | 16,750
Female tissues 256 | 17,400
Skin and soft tissues 256 | 17,230
Urinary Tract 256 | 16,678
Male tissues 254 | 17,142
Blood and immune system 249 | 16,909
Respiratory system 243 | 16,393
Nervous System 238 | 16,725
Cardiovascular System 222 | 15,192

Target Family

Non-IDG 150 | 12,091
Enzyme 71 | 4,145
GPCR 11 | 408
Kinase 11 | 634
Transcription Factor 10 | 1,400
Transporter 9 | 473
Nuclear Receptor 4 | 48
Ion Channel 2 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171