Development Level

Tbio 129 | 10,625
Tchem 67 | 1,890
Tclin 40 | 602
Tdark 4 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 13 | 633
embryonic lethality prior to t... 5 | 187
enlarged heart 4 | 111
preweaning lethality, incomple... 4 | 260
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased circulating insulin ... 3 | 75
decreased circulating triglyce... 3 | 83
decreased monocyte cell number 3 | 28
enlarged epididymis 3 | 27
increased grip strength 3 | 83
increased leukocyte cell numbe... 3 | 37
increased lymphocyte cell numb... 3 | 9
short tibia 3 | 82
abnormal epididymis morphology 2 | 31
abnormal seminal vesicle morph... 2 | 47
abnormal snout morphology 2 | 18
abnormal vibrissa morphology 2 | 17
cataract 2 | 26
decreased circulating LDL chol... 2 | 37
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
increased body weight 2 | 42
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 53
increased circulating triglyce... 2 | 24
increased or absent threshold ... 2 | 128
tremors 2 | 34
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal eye anterior chamber ... 1 | 3
abnormal forced expiratory flo... 1 | 1
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body temperature 1 | 2
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 5
decreased circulating alkaline... 1 | 41
decreased circulating aspartat... 1 | 27
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
enlarged spleen 1 | 26
enlarged uterus 1 | 3
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating free fat... 1 | 17
increased circulating total pr... 1 | 20
increased eosinophil cell numb... 1 | 9
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased total body fat amoun... 1 | 57
long tibia 1 | 13
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
prolonged PR interval 1 | 4
small kidney 1 | 10
stereotypic behavior 1 | 3
trunk curl 1 | 15

Disease

Coronary artery disease 240 | 240
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 238 | 18,473
Female tissues 238 | 18,647
Blood and immune system 237 | 17,995
Cardiovascular System 237 | 17,958
Endocrine System 237 | 18,512
Nervous System 237 | 18,561
Urinary Tract 237 | 18,444
Liver and Pancreas 236 | 18,136
Male tissues 236 | 17,969
Skin and soft tissues 236 | 18,115
Respiratory system 235 | 17,484

Target Family

Non-IDG 137 | 11,971
Enzyme 67 | 4,146
GPCR 8 | 406
Transcription Factor 8 | 1,400
Transporter 8 | 473
Kinase 7 | 634
Nuclear Receptor 4 | 48
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901