Development Level

Tbio 150 | 11,651
Tchem 50 | 1,388
Tclin 32 | 612
Tdark 11 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 10 | 499
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 6 | 220
abnormal behavior 5 | 298
decreased body weight 5 | 161
decreased lean body mass 5 | 135
enlarged heart 5 | 210
increased startle reflex 5 | 112
decreased total body fat amoun... 4 | 207
impaired righting response 4 | 26
increased mean corpuscular hem... 4 | 96
short tibia 4 | 97
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal sleep behavior 3 | 70
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased vertical activity 3 | 208
increased bone mineral content 3 | 108
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal facial morphology 2 | 17
abnormal head shape 2 | 10
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
abnormal response to tactile s... 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
abnormal vibrissa morphology 2 | 25
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased heart left ventricle... 2 | 28
decreased heart weight 2 | 27
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased total retina thickne... 2 | 17
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased heart rate 2 | 23
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
male infertility 2 | 123
mammalian phenotype 2 | 17
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small adrenal glands 2 | 16
small testis 2 | 58
thin ventricular wall 2 | 24
vertebral fusion 2 | 23
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 12
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
enlarged spleen 1 | 41
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28

Disease

Colorectal Neoplasms 243 | 243
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 239 | 18,159
Female tissues 236 | 17,400
Male tissues 236 | 17,142
Skin and soft tissues 236 | 17,230
Digestive Tract 234 | 17,369
Nervous System 233 | 16,725
Urinary Tract 233 | 16,678
Blood and immune system 232 | 16,909
Respiratory system 231 | 16,393
Liver and Pancreas 229 | 16,750
Cardiovascular System 214 | 15,192

Target Family

Non-IDG 100 | 12,091
Enzyme 57 | 4,145
Transporter 32 | 473
Kinase 20 | 634
Transcription Factor 19 | 1,400
Epigenetic 5 | 242
Ion Channel 4 | 344
GPCR 3 | 408
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275