Development Level

Tbio 122 | 10,625
Tchem 57 | 1,890
Tclin 29 | 602
Tdark 9 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 17 | 633
decreased body weight 5 | 174
decreased bone mineral density 5 | 126
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
abnormal bone mineralization 4 | 55
abnormal embryo size 4 | 112
decreased grip strength 4 | 123
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
abnormal behavior 3 | 226
abnormal retina morphology 3 | 100
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased total body fat amoun... 3 | 186
increased or absent threshold ... 3 | 128
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal lung morphology 2 | 15
abnormal response to tactile s... 2 | 16
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal startle reflex 2 | 14
abnormal testis morphology 2 | 30
abnormal thoracic vertebrae mo... 2 | 16
cataract 2 | 26
decreased CD4-positive, alpha ... 2 | 19
decreased blood urea nitrogen ... 2 | 31
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 19
decreased rib number 2 | 59
hypoactivity 2 | 89
impaired righting response 2 | 19
increased bone mineral content 2 | 92
increased circulating potassiu... 2 | 31
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
small adrenal glands 2 | 15
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal head size 1 | 1
abnormal kidney morphology 1 | 30
abnormal neural tube morpholog... 1 | 8
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 2
absent vibrissae 1 | 14
craniofacial phenotype 1 | 9
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased threshold for audito... 1 | 32
hydrops fetalis 1 | 22
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 25
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
vertebral fusion 1 | 23

Disease

Colorectal Neoplasms 217 | 217
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 215 | 17,995
Cardiovascular System 215 | 17,958
Endocrine System 215 | 18,512
Female tissues 215 | 18,647
Nervous System 215 | 18,561
Skin and soft tissues 215 | 18,115
Urinary Tract 215 | 18,444
Digestive Tract 214 | 18,473
Liver and Pancreas 214 | 18,136
Male tissues 213 | 17,969
Respiratory system 213 | 17,484

Target Family

Non-IDG 87 | 11,971
Enzyme 50 | 4,146
Transporter 32 | 473
Kinase 19 | 634
Transcription Factor 18 | 1,400
Ion Channel 4 | 341
Nuclear Receptor 3 | 48
Epigenetic 2 | 242
GPCR 2 | 406

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.39868 2437.0 1167
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
Forkhead box protein L2 FOXL2 Tbio Transcription Factor -2.76212 610.7 220
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 Tdark Non-IDG -0.97425 9.04 11
Bone morphogenetic protein 4 BMP4 Tchem Non-IDG -3.16723 1539.5 438
Selenoprotein P SELENOP Tbio Non-IDG -2.42408 315.2 94
Proliferation marker protein Ki-67 MKI67 Tbio Non-IDG -2.46535 260.9 996