Development Level

Tbio 60 | 10,625
Tchem 45 | 1,890
Tclin 21 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 8 | 633
decreased lean body mass 4 | 195
decreased body weight 3 | 174
decreased mean corpuscular hem... 3 | 19
decreased total body fat amoun... 3 | 186
enlarged heart 3 | 111
abnormal bone mineralization 2 | 55
abnormal epididymis morphology 2 | 31
abnormal heart morphology 2 | 51
abnormal posture 2 | 5
abnormal startle reflex 2 | 14
decreased body length 2 | 108
decreased circulating iron lev... 2 | 25
decreased grip strength 2 | 123
decreased heart weight 2 | 44
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 2
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal pharyngeal arch morph... 1 | 2
abnormal sacral vertebrae morp... 1 | 5
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
cataract 1 | 26
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased thermal nociceptive ... 1 | 4
embryonic growth retardation 1 | 28
enlarged epididymis 1 | 27
enlarged heart atrium 1 | 2
enlarged spleen 1 | 26
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased grip strength 1 | 83
increased heart rate 1 | 17
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 35
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened RR interval 1 | 19
small testis 1 | 37

Disease

Colonic Neoplasms 126 | 126
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 126 | 18,473
Female tissues 126 | 18,647
Liver and Pancreas 126 | 18,136
Blood and immune system 125 | 17,995
Endocrine System 125 | 18,512
Nervous System 125 | 18,561
Skin and soft tissues 125 | 18,115
Urinary Tract 125 | 18,444
Cardiovascular System 124 | 17,958
Male tissues 124 | 17,969
Respiratory system 124 | 17,484

Target Family

Non-IDG 59 | 11,969
Enzyme 36 | 4,146
Transcription Factor 12 | 1,400
Kinase 6 | 634
Transporter 6 | 473
GPCR 2 | 408
Ion Channel 2 | 341
Epigenetic 1 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Defensin-5 DEFA5 Tbio Non-IDG -1.89753 82.9 161
Axin-2 AXIN2 Tchem Non-IDG -2.41017 219.7 225
Folate transporter 1 SLC19A1 Tchem Transporter -1.98678 92.5 52
SERTA domain-containing protein 1 SERTAD1 Tbio Non-IDG -1.19514 19.6 114
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.16754 1415.1 1015
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.89186 64.6 443
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.97802 99.5 138
Protein S100-A4 S100A4 Tbio Non-IDG -2.74160 600.8 370
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539