Development Level

Tbio 117 | 11,651
Tchem 50 | 1,388
Tclin 20 | 612
Tdark 8 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
abnormal heart morphology 5 | 162
decreased mean corpuscular vol... 5 | 79
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
decreased circulating glucose ... 4 | 126
embryonic lethality prior to o... 4 | 239
increased startle reflex 4 | 112
abnormal embryo size 3 | 220
abnormal seminal vesicle morph... 3 | 114
decreased vertical activity 3 | 208
preweaning lethality, complete... 3 | 979
abnormal testis morphology 2 | 43
corneal opacity 2 | 32
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alanine ... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 12
brachydactyly 1 | 19
corneal vascularization 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
enlarged adrenal glands 1 | 3
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
short tibia 1 | 97
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Chemical and Drug Induced Liver Injury 195 | 195
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 188 | 17,369
Skin and soft tissues 186 | 17,230
Liver and Pancreas 185 | 16,750
Female tissues 184 | 17,400
Male tissues 184 | 17,142
Endocrine System 183 | 18,159
Urinary Tract 183 | 16,678
Blood and immune system 180 | 16,909
Respiratory system 177 | 16,393
Nervous System 174 | 16,725
Cardiovascular System 160 | 15,192

Target Family

Non-IDG 90 | 12,091
Enzyme 70 | 4,145
Kinase 8 | 634
Transcription Factor 7 | 1,400
Transporter 7 | 473
GPCR 5 | 408
Nuclear Receptor 5 | 48
Ion Channel 2 | 344
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Cathepsin E CTSE Tchem Enzyme -2.33724 227.7 192
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48812 30.2 69
Nuclear receptor subfamily 1 group I member 3 NR1I3 Tchem Nuclear Receptor -2.57140 281.2 304
C-C chemokine receptor type 2 CCR2 Tchem GPCR -3.06548 1112.4 530
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 PAN2 Tbio Enzyme -0.66901 4.14 87