Development Level

Tbio 222 | 11,651
Tclin 46 | 612
Tchem 30 | 1,388
Tdark 6 | 6,593

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 44 | 979
embryonic lethality prior to o... 16 | 239
embryonic lethality prior to t... 15 | 278
abnormal behavior 8 | 298
abnormal embryo size 6 | 220
decreased total body fat amoun... 6 | 207
increased lean body mass 6 | 172
male infertility 6 | 123
preweaning lethality, incomple... 6 | 499
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
increased bone mineral content 5 | 108
increased total body fat amoun... 5 | 134
abnormal bone structure 4 | 187
decreased mean corpuscular vol... 4 | 79
embryonic growth retardation 4 | 106
hyperactivity 4 | 148
increased or absent threshold ... 4 | 101
abnormal neural tube closure 3 | 46
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating HDL chol... 3 | 68
decreased circulating calcium ... 3 | 36
decreased circulating creatini... 3 | 39
decreased hemoglobin content 3 | 68
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal heart morphology 2 | 162
abnormal hindbrain development 2 | 16
abnormal midbrain development 2 | 20
abnormal seminal vesicle morph... 2 | 114
absent pinna reflex 2 | 23
absent startle reflex 2 | 24
decreased basophil cell number 2 | 16
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean platelet volume 2 | 25
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
impaired righting response 2 | 26
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating aspartat... 2 | 15
increased circulating choleste... 2 | 66
increased startle reflex 2 | 112
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
prolonged ST segment 2 | 36
short tibia 2 | 97
small epididymis 2 | 3
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal cornea morphology 1 | 31
abnormal ear morphology 1 | 9
abnormal gait 1 | 69
abnormal sleep behavior 1 | 70
abnormal vibrissa morphology 1 | 25
decreased caudal vertebrae num... 1 | 53
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Cerebellar Ataxia 304 | 304
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 301 | 18,159
Digestive Tract 298 | 17,369
Female tissues 297 | 17,400
Nervous System 297 | 16,725
Male tissues 296 | 17,142
Blood and immune system 293 | 16,909
Skin and soft tissues 292 | 17,230
Liver and Pancreas 290 | 16,750
Urinary Tract 290 | 16,678
Respiratory system 286 | 16,393
Cardiovascular System 279 | 15,192

Target Family

Non-IDG 130 | 12,091
Enzyme 123 | 4,145
Ion Channel 18 | 344
Kinase 13 | 634
Transporter 11 | 473
Transcription Factor 5 | 1,400
GPCR 2 | 408
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
Transmembrane protein 70, mitochondrial TMEM70 Tbio Non-IDG -1.36229 24.6 93
Protein Mpv17 MPV17 Tbio Non-IDG -1.67807 47.6 134
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase ALG6 Tbio Enzyme -1.41256 26.8 76
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 NDUFAF3 Tclin Enzyme -2.16371 139.2 56