Development Level

Tbio 18 | 11,445
Tclin 6 | 613
Tchem 4 | 1,598

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
increased fasted circulating g... 2 | 76
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal skin morphology 1 | 50
abnormal stomach morphology 1 | 10
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased blood urea nitrogen ... 1 | 51
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
enlarged uterus 1 | 11
hydrometra 1 | 53
increased body weight 1 | 25
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
long tibia 1 | 25
male infertility 1 | 123
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
small kidney 1 | 16
small superior vagus ganglion 1 | 74
syndactyly 1 | 23

Disease

Carcinoma, Basal Cell 28 | 28
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 28 | 18,159
Digestive Tract 27 | 17,369
Female tissues 27 | 17,400
Skin and soft tissues 27 | 17,230
Blood and immune system 26 | 16,909
Cardiovascular System 26 | 15,192
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Urinary Tract 26 | 16,678
Nervous System 25 | 16,725
Respiratory system 24 | 16,393

Target Family

Non-IDG 12 | 12,091
Enzyme 7 | 4,145
Kinase 3 | 634
Transcription Factor 3 | 1,400
GPCR 2 | 408
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92
Serine/threonine-protein kinase 19 STK19 Tbio Enzyme -1.86010 71.6 142
Tyrosinase TYR Tclin Enzyme -3.32888 2021.2 494
Serine/threonine-protein phosphatase 6 catalytic subunit PPP6C Tbio Enzyme -2.41091 208.5 230
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Keratin, type II cytoskeletal 5 KRT5 Tbio Non-IDG -2.87489 691.1 885
Telomerase reverse transcriptase TERT Tchem Enzyme -3.56910 3506.4 643