Development Level

Tbio 1,284 | 10,625
Tdark 419 | 7,003
Tchem 287 | 1,890
Tclin 157 | 602

Collection

Kinase: IDG Consortium (Targets) 20 | 125
Ion Channel: IDG Consortium (Targets) 11 | 102
GPCR: IDG Consortium (Targets) 10 | 127
Kinase: IDG Consortium (Complete/Control) 10 | 37
GPCR: IDG Consortium (Complete/Control) 2 | 26

IMPC Phenotype

preweaning lethality, complete... 86 | 633
preweaning lethality, incomple... 36 | 260
decreased lean body mass 34 | 195
decreased total body fat amoun... 32 | 186
abnormal embryo size 29 | 112
abnormal behavior 28 | 226
embryonic lethality prior to t... 28 | 187
decreased body weight 26 | 174
embryonic lethality prior to o... 22 | 148
decreased bone mineral density 21 | 126
decreased bone mineral content 20 | 157
decreased grip strength 20 | 123
abnormal bone structure 19 | 131
decreased body length 18 | 108
increased bone mineral content 18 | 92
increased or absent threshold ... 17 | 128
decreased circulating serum al... 16 | 79
abnormal retina morphology 15 | 100
decreased circulating choleste... 15 | 85
decreased circulating glucose ... 15 | 121
increased lean body mass 15 | 107
decreased circulating HDL chol... 14 | 77
impaired glucose tolerance 14 | 52
increased mean corpuscular hem... 14 | 93
short tibia 14 | 82
abnormal neural tube closure 13 | 37
increased circulating alkaline... 13 | 119
decreased circulating total pr... 12 | 41
hyperactivity 12 | 108
hypoactivity 12 | 89
abnormal lens morphology 11 | 73
decreased lumbar vertebrae num... 11 | 62
increased circulating sodium l... 11 | 71
abnormal bone mineralization 10 | 55
decreased circulating alanine ... 10 | 53
decreased hemoglobin content 10 | 53
decreased leukocyte cell numbe... 10 | 54
enlarged heart 10 | 111
increased blood urea nitrogen ... 10 | 44
increased fasted circulating g... 10 | 68
male infertility 10 | 62
abnormal hindbrain development 9 | 24
decreased circulating free fat... 9 | 39
decreased prepulse inhibition 9 | 52
increased bone mineral density 9 | 52
increased circulating HDL chol... 9 | 63
increased sacral vertebrae num... 9 | 62
abnormal gait 8 | 51
abnormal midbrain development 8 | 22
abnormal sleep behavior 8 | 63
improved glucose tolerance 8 | 56
increased mean corpuscular vol... 8 | 91
abnormal coat-hair pigmentatio... 7 | 54
abnormal forebrain development 7 | 18
cardiovascular system phenotyp... 7 | 35
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating alkaline... 7 | 41
decreased circulating fructosa... 7 | 31
decreased circulating triglyce... 7 | 83
decreased erythrocyte cell num... 7 | 43
decreased hematocrit 7 | 25
decreased mean corpuscular hem... 7 | 34
decreased mean corpuscular vol... 7 | 50
decreased startle reflex 7 | 48
increased grip strength 7 | 83
increased heart weight 7 | 37
increased hematocrit 7 | 36
increased startle reflex 7 | 38
thrombocytopenia 7 | 46
abnormal cranium morphology 6 | 32
abnormal retinal pigmentation 6 | 61
abnormal seminal vesicle morph... 6 | 47
abnormal tooth morphology 6 | 24
decreased caudal vertebrae num... 6 | 49
decreased circulating creatini... 6 | 31
decreased circulating insulin ... 6 | 75
decreased eosinophil cell numb... 6 | 41
decreased fasted circulating g... 6 | 49
decreased heart weight 6 | 44
increased circulating choleste... 6 | 53
increased circulating potassiu... 6 | 31
increased total body fat amoun... 6 | 57
limb grasping 6 | 35
abnormal behavioral response t... 5 | 52
abnormal cornea morphology 5 | 24
abnormal eye morphology 5 | 38
abnormal head morphology 5 | 10
abnormal heart left ventricle ... 5 | 20
abnormal locomotor activation 5 | 26
abnormal startle reflex 5 | 14
corneal opacity 5 | 25
decreased blood urea nitrogen ... 5 | 31
decreased circulating aspartat... 5 | 27
increased body weight 5 | 42
increased circulating creatini... 5 | 29
persistence of hyaloid vascula... 5 | 22
prenatal lethality prior to he... 5 | 64
small testis 5 | 37
small thymus 5 | 11

Disease

Carcinoma 2,147 | 2,147
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 2,126 | 18,646
Digestive Tract 2,122 | 18,472
Nervous System 2,121 | 18,560
Endocrine System 2,114 | 18,511
Urinary Tract 2,113 | 18,443
Liver and Pancreas 2,099 | 18,135
Cardiovascular System 2,098 | 17,957
Male tissues 2,097 | 17,968
Blood and immune system 2,087 | 17,994
Skin and soft tissues 2,082 | 18,114
Respiratory system 2,055 | 17,483

Target Family

Non-IDG 1,201 | 11,969
Enzyme 336 | 4,146
Kinase 151 | 634
Transcription Factor 136 | 1,400
Ion Channel 103 | 341
Transporter 73 | 473
Epigenetic 68 | 242
GPCR 49 | 408
TF/Epigenetic 15 | 38
oGPCR 11 | 421
Nuclear Receptor 4 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Myelin transcription factor 1-like protein MYT1L Tbio Transcription Factor -1.43180 24.8 41
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.22055 159.7 209
Trafficking protein particle complex subunit 9 TRAPPC9 Tbio Non-IDG -2.14008 133.3 71
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
High affinity nerve growth factor receptor NTRK1 Tchem Kinase -3.03552 1003.4 1000
Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 Tdark Non-IDG 0.19 0.86 20