Development Level

Tbio 7,198 | 11,651
Tdark 2,783 | 6,593
Tchem 1,042 | 1,388
Tclin 470 | 612

Collection

Kinase: IDG Consortium (Target... 98 | 125
GPCR: IDG Consortium (Targets) 82 | 126
Ion Channel: IDG Consortium (T... 68 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 655 | 979
preweaning lethality, incomple... 344 | 499
abnormal behavior 201 | 298
embryonic lethality prior to t... 178 | 278
abnormal embryo size 148 | 220
embryonic lethality prior to o... 145 | 239
decreased total body fat amoun... 143 | 207
abnormal bone structure 138 | 187
decreased body weight 134 | 161
increased lean body mass 123 | 172
enlarged heart 119 | 210
decreased vertical activity 114 | 208
decreased bone mineral content 103 | 151
hyperactivity 97 | 148
decreased bone mineral density 95 | 126
hypoactivity 94 | 132
decreased lean body mass 93 | 135
male infertility 93 | 123
abnormal heart morphology 92 | 162
increased total body fat amoun... 90 | 134
decreased circulating glucose ... 83 | 126
increased circulating alkaline... 82 | 122
increased startle reflex 82 | 112
decreased grip strength 79 | 116
decreased circulating choleste... 77 | 93
increased bone mineral content 75 | 108
increased or absent threshold ... 74 | 101
decreased body length 73 | 101
embryonic growth retardation 71 | 106
short tibia 70 | 97
increased mean corpuscular hem... 66 | 96
abnormal seminal vesicle morph... 64 | 114
decreased prepulse inhibition 63 | 82
increased mean corpuscular vol... 60 | 92
impaired glucose tolerance 59 | 75
decreased startle reflex 58 | 75
prenatal lethality prior to he... 58 | 87
decreased circulating triglyce... 56 | 79
decreased lymphocyte cell numb... 55 | 83
decreased mean corpuscular vol... 55 | 79
increased bone mineral density 54 | 72
increased circulating HDL chol... 54 | 80
cataract 53 | 92
decreased circulating serum al... 52 | 82
decreased hemoglobin content 52 | 68
increased heart weight 52 | 62
decreased circulating HDL chol... 51 | 68
improved glucose tolerance 51 | 79
abnormal retina morphology 50 | 71
decreased leukocyte cell numbe... 50 | 73
abnormal lens morphology 49 | 81
increased circulating choleste... 46 | 66
increased fasted circulating g... 45 | 76
abnormal behavioral response t... 44 | 66
decreased fasted circulating g... 44 | 65
increased monocyte cell number 44 | 63
abnormal eye morphology 43 | 68
decreased circulating insulin ... 43 | 76
increased circulating sodium l... 43 | 71
abnormal sleep behavior 42 | 70
thrombocytopenia 42 | 56
abnormal gait 41 | 69
decreased circulating alanine ... 40 | 47
female infertility 39 | 60
abnormal kidney morphology 38 | 65
decreased blood urea nitrogen ... 38 | 51
decreased caudal vertebrae num... 38 | 53
edema 38 | 59
decreased mean corpuscular hem... 37 | 50
small superior vagus ganglion 37 | 74
abnormal coat-hair pigmentatio... 36 | 64
decreased circulating total pr... 36 | 49
increased hemoglobin content 36 | 45
decreased circulating alkaline... 35 | 46
decreased erythrocyte cell num... 35 | 62
increased mean platelet volume 35 | 45
small testis 35 | 58
abnormal bone mineralization 33 | 38
increased leukocyte cell numbe... 33 | 47
abnormal spleen morphology 32 | 55
decreased circulating LDL chol... 32 | 38
increased circulating triglyce... 32 | 42
increased grip strength 32 | 41
increased hematocrit 32 | 46
abnormal cranium morphology 31 | 36
increased blood urea nitrogen ... 31 | 48
tremors 31 | 39
decreased hematocrit 30 | 46
decreased neutrophil cell numb... 29 | 42
enlarged spleen 29 | 41
abnormal neural tube closure 28 | 46
abnormal skin morphology 28 | 50
enlarged lymph nodes 28 | 37
increased erythrocyte cell num... 28 | 39
abnormal epididymis morphology 27 | 42
cardiovascular system phenotyp... 27 | 36
decreased circulating aspartat... 27 | 34
increased circulating chloride... 27 | 41
increased neutrophil cell numb... 27 | 46
limb grasping 27 | 41

Disease

Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 10,923 | 18,159
Female tissues 10,539 | 17,400
Digestive Tract 10,497 | 17,369
Skin and soft tissues 10,434 | 17,230
Male tissues 10,395 | 17,142
Blood and immune system 10,221 | 16,909
Nervous System 10,212 | 16,725
Liver and Pancreas 10,190 | 16,750
Urinary Tract 10,186 | 16,678
Respiratory system 9,965 | 16,393
Cardiovascular System 9,316 | 15,192

Target Family

Non-IDG 6,071 | 12,091
Enzyme 2,459 | 4,145
Transcription Factor 938 | 1,400
Kinase 511 | 634
Transporter 358 | 473
oGPCR 319 | 421
GPCR 302 | 408
Ion Channel 269 | 344
Epigenetic 190 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66